Analysis of immune responses of different hosts to Babesia divergens isolates from different geographic areas and capacity of culture-derived exoantigens to induce efficient cross-protection
| Autor: | P Brasseur, E Precigout, B. Carcy, G Bissuel, Y Moreau, Alexis Valentin, A Gorenflot, Joseph Schrével |
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| Jazyk: | angličtina |
| Rok vydání: | 1991 |
| Předmět: |
Protozoan Vaccines
Antigenicity Octoxynol animal diseases Immunology Detergents Virulence Antibodies Protozoan Babesia Antigens Protozoan Cross Reactions Microbiology Epitope Polyethylene Glycols Epitopes Antigen Babesiosis medicine Animals Humans Babesia divergens Pathogen biology biology.organism_classification medicine.disease Virology Precipitin Tests Infectious Diseases Solubility Parasitology Cattle Immunization Gerbillinae Peptides Research Article |
| Popis: | The immunoprecipitation of [35S]methionine-radiolabelled antigens from different Babesia divergens isolates by using bovine, gerbil, and human immune sera has shown that many B. divergens proteins contain epitopes shared between isolates. The cross-protective capacity of culture-derived soluble immunogens from the B. divergens Rouen 1987 isolate was tested against different B. divergens isolates. Results showed complete protection against the 7107b French isolate and substantial protection against the Weybridge 8843 English isolate (80% protection) and the Munich 87 German isolate (60% protection). In order to explain these vaccination results and to assess both the common and variable antigenicity of B. divergens, the antigenic patterns of the challenge isolates (Rouen 1987, 7107b, Weybridge 8843, and Munich 87) were compared by immunoprecipitation, using gerbil antisera raised against the Rouen 1987 vaccine isolate. Differences in the antigenic patterns and in the cross-protection of gerbils in these heterologous challenges were examined by studying the virulence and the antigenic status of each isolate. |
| Databáze: | OpenAIRE |
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