Ultra-High-Resolution Imaging of Amygdala Subnuclei Structural Connectivity in Major Depressive Disorder
| Autor: | Gaurav Verma, Molly Schneider, John W. Rutland, Priti Balchandani, Stephanie S. G. Brown, Rebecca Feldman, Bradley N. Delman, James M. Murrough |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Cognitive Neuroscience Amygdala Article 050105 experimental psychology Lateralization of brain function Young Adult 03 medical and health sciences 0302 clinical medicine Neuroimaging medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Biological Psychiatry Depressive Disorder Major medicine.diagnostic_test business.industry 05 social sciences Magnetic resonance imaging Middle Aged medicine.disease Magnetic Resonance Imaging White Matter Diffusion Magnetic Resonance Imaging medicine.anatomical_structure Mood disorders Major depressive disorder Female Neurology (clinical) business Neuroscience 030217 neurology & neurosurgery Tractography Diffusion MRI |
| Zdroj: | Biol Psychiatry Cogn Neurosci Neuroimaging |
| ISSN: | 2451-9022 |
| DOI: | 10.1016/j.bpsc.2019.07.010 |
| Popis: | Major depressive disorder (MDD) is an increasingly common and disabling illness. As the amygdala has been reported to have pathological involvement in mood disorders, we aimed to investigate for the first time potential changes to structural connectivity of individual amygdala subnuclei in MDD using ultra-high-field 7T diffusion magnetic resonance imaging.Twenty-four patients with MDD (11 women) and 24 age-matched healthy control participants (7 women) underwent diffusion-weighted imaging with a 1.05-mm isotropic resolution at 7T. Amygdala nuclei regions of interest were obtained through automated segmentation of 0.69-mm resolution T1-weighted images and 0.35-mm resolution T2-weighted images. Probabilistic tractography was performed on all subjects, with random seeding at each amygdala nucleus.The right lateral, basal, central, and centrocortical amygdala nuclei exhibited significantly increased connection density to the rest of the brain, whereas the left medial nucleus demonstrated significantly lower connection density (false discovery rate p.05). Increased connection density in the right lateral and basal nuclei was driven by the stria terminalis, and the significant difference in the right central nucleus was driven by the uncinate fasciculus. Decreased connection density at the left medial nucleus did not appear to be driven by any individual white matter tract.By exploiting ultra-high-resolution magnetic resonance imaging, structural hyperconnectivity was demonstrated involving the amygdaloid nuclei in the right hemisphere in MDD. To a lesser extent, impairment of subnuclei connectivity was shown in the left hemisphere. |
| Databáze: | OpenAIRE |
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