Outcomes of pelvic exenteration for locally advanced primary rectal cancer: Overall survival and quality of life
| Autor: | Lindy Masya, Michael J. Solomon, Rachael Roberts, Tim Badgery-Parker, A. J. Quyn, Jane M. Young, Kirk K. S. Austin |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male medicine.medical_specialty Colorectal cancer medicine.medical_treatment Locally advanced Kaplan-Meier Estimate 030230 surgery 03 medical and health sciences 0302 clinical medicine Quality of life medicine Overall survival Humans Radical surgery Aged Aged 80 and over Pelvic exenteration Rectal Neoplasms business.industry Cancer General Medicine Length of Stay Middle Aged medicine.disease Pelvic Exenteration Surgery Treatment Outcome Oncology 030220 oncology & carcinogenesis Cohort Quality of Life Female Self Report New South Wales business Follow-Up Studies |
| Zdroj: | European Journal of Surgical Oncology (EJSO). 42:823-828 |
| ISSN: | 0748-7983 |
| DOI: | 10.1016/j.ejso.2016.02.016 |
| Popis: | Introduction Radical surgery with pelvic exenteration offers the only potential for cure in patients with locally advanced primary rectal cancer. This study describes the clinical and patient-reported quality of life outcomes over 12 months for patients having pelvic exenteration for locally advanced primary rectal cancer at a specialised centre for pelvic exenteration. Methods Clinical data of consecutive patients undergoing pelvic exenteration for locally advanced primary rectal cancer and patient-reported outcomes were collected at baseline, hospital discharge and at 1, 3, 6, 9 and 12 months. Patient-reported outcomes included cancer-specific quality of life (QoL) and physical and mental health status. Quality of life trajectories were modelled over the 12 months from the date of surgery using linear mixed models. Results 104 patients with locally advanced rectal cancer underwent pelvic exenteration at Royal Prince Alfred Hospital, Sydney, between December 1994 and October 2014. Complete soft tissue exenteration was performed in 38%. A clear margin was obtained in 86% with a 62% overall five-year survival. QoL outcome questionnaires were completed by 62% of patient cohort. The average FACT-C score returned to pre-surgery QoL by 2 months after surgery, and the average QoL continued to increase slowly over the 12 months. Conclusion Our results support an aggressive approach to advanced primary rectal cancer and lend weight to the oncological role of pelvic exenteration for this group of patients. Quality of life improves rapidly after pelvic exenteration for locally advanced primary rectal cancer and continues to improve over the first year. |
| Databáze: | OpenAIRE |
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