Di-copper(ii) DNA G-quadruplexes as EPR distance rulers
| Autor: | Olav Schiemann, David M. Engelhard, Guido H. Clever, Andreas J. Meyer, Andreas Berndhäuser |
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| Rok vydání: | 2018 |
| Předmět: |
Pyridines
chemistry.chemical_element Molecular Dynamics Simulation 010402 general chemistry G-quadruplex 01 natural sciences Catalysis law.invention Metal chemistry.chemical_compound Transition metal law Coordination Complexes Pyridine Materials Chemistry Molecule Electron paramagnetic resonance Molecular Structure 010405 organic chemistry Chemistry Metals and Alloys Electron Spin Resonance Spectroscopy General Chemistry DNA Copper 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials G-Quadruplexes Crystallography Covalent bond visual_art Ceramics and Composites visual_art.visual_art_medium Spin Labels |
| Zdroj: | Chemical communications (Cambridge, England). 54(54) |
| ISSN: | 1364-548X |
| Popis: | Artificial metal-base tetrads composed of square-planar CuII(pyridine)4 complexes were covalently attached to both the 3' and 5' ends of tetramolecular DNA G-quadruplexes [Ld(G3-5)LdT]4 (L = pyridine ligand) of different lengths. Owing to the planar four-point attachment of the metal complexes, the magnetic orbitals (dx2-y2) of the d9-configured CuII cations are placed in a coplanar fashion, separated by the stacked guanine tetrads. Pulsed EPR-derived CuII-CuII distances and angles were found to be in agreement with those obtained from molecular dynamics simulations. DNA-confined transition metal spin labels open new ways to study oligonucleotide structure and DNA-protein complexes. |
| Databáze: | OpenAIRE |
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