Diurnal rhythms across the human dorsal and ventral striatum
| Autor: | George C. Tseng, Wei Zong, Jill R. Glausier, Vaishnavi G. Shankar, Kelly M. Cahill, Madeline R. Scott, David A. Lewis, Kyle D. Ketchesin, Colleen A. McClung, Marianne L. Seney, Mariah A. Hildebrand |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Circadian clock Striatum Biology Nucleus accumbens Nucleus Accumbens 03 medical and health sciences 0302 clinical medicine Rhythm Circadian Clocks medicine Humans Circadian rhythm Multidisciplinary Putamen Ventral striatum Brain Human brain Biological Sciences Circadian Rhythm 030104 developmental biology medicine.anatomical_structure nervous system Ventral Striatum Transcriptome Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Proc Natl Acad Sci U S A |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.2016150118 |
| Popis: | The human striatum can be subdivided into the caudate, putamen, and nucleus accumbens (NAc). Each of these structures have some overlapping and some distinct functions related to motor control, cognitive processing, motivation, and reward. Previously, we used a "time-of-death" approach to identify diurnal rhythms in RNA transcripts in human cortical regions. Here, we identify molecular rhythms across the three striatal subregions collected from postmortem human brain tissue in subjects without psychiatric or neurological disorders. Core circadian clock genes are rhythmic across all three regions and show strong phase concordance across regions. However, the putamen contains a much larger number of significantly rhythmic transcripts than the other two regions. Moreover, there are many differences in pathways that are rhythmic across regions. Strikingly, the top rhythmic transcripts in NAc (but not the other regions) are predominantly small nucleolar RNAs and long noncoding RNAs, suggesting that a completely different mechanism might be used for the regulation of diurnal rhythms in translation and/or RNA processing in the NAc versus the other regions. Further, although the NAc and putamen are generally in phase with regard to timing of expression rhythms, the NAc and caudate, and caudate and putamen, have several clusters of discordant rhythmic transcripts, suggesting a temporal wave of specific cellular processes across the striatum. Taken together, these studies reveal distinct transcriptome rhythms across the human striatum and are an important step in helping to understand the normal function of diurnal rhythms in these regions and how disruption could lead to pathology. |
| Databáze: | OpenAIRE |
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