Relationship Between C-Reactive Protein to Albumin Ratio and Infarct-Related Artery Patency in Patients With ST-Segment Elevation Myocardial Infarction
| Autor: | Mustafa Karanfil, Adnan Burak Akcay, Ahmet Göktuğ Ertem, Çağrı Yayla, Mehmet Akif Erdöl, Kadriye Gayretli Yayla |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Myocardial Infarction 030204 cardiovascular system & hematology Coronary Angiography 03 medical and health sciences Percutaneous Coronary Intervention 0302 clinical medicine Predictive Value of Tests Albumins Internal medicine Humans Medicine ST segment cardiovascular diseases Myocardial infarction Vascular Patency Predictive marker biology business.industry C-reactive protein Area under the curve Arteries Thrombolysis medicine.disease C-Reactive Protein medicine.anatomical_structure Infarction 030220 oncology & carcinogenesis biology.protein Cardiology ST Elevation Myocardial Infarction Cardiology and Cardiovascular Medicine business TIMI Artery |
| Zdroj: | Angiology. 73:260-264 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/00033197211024047 |
| Popis: | The C-reactive protein to albumin ratio (CAR) is a predictive marker of systemic inflammatory state in atherosclerotic coronary disease when compared with the predictive value of these 2 markers separately. We investigated the relationship between CAR and infarct-related artery (IRA) patency in patients with ST-segment elevation myocardial infarction (STEMI). The study population (n = 1047) was divided into 2 groups according to IRA patency which was assessed by the Thrombolysis in Myocardial Infarction (TIMI) flow grade. Nonpatent flow was defined as TIMI grade 0 (no-reflow), 1, and 2 flows, and normal flow was defined as TIMI 3 flow. There was a significant positive correlation between CAR and SYNTAX score ( r = 0.312, P < .001) and a negative correlation between CAR and TIMI grade flow ( r = −0.210, P < .001). At a cutoff level of 0.693, the CAR predicted TIMI no-reflow with a sensitivity of 65.4% and a specificity of 65.5% (area under the curve: 0.670, 95% CI: 0.62-0.71, P < .001). Multivariate logistic regression analyses showed that CAR was an independent predictor of IRA patency (0.003 [0.001-0.029]; P < .001). A higher CAR is a significant and independent predictor of IRA patency in patients with STEMI. |
| Databáze: | OpenAIRE |
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