Survival of HIV/HCV co-infected patients before introduction of HCV direct acting antivirals (DAA)

Autor:	Juergen K. Rockstroh, Christoph Boesecke, Leona Dold, Bettina Langhans, Christian P. Strassburg, Ulrich Spengler, Jan-Christian Wasmuth, Carolynne Schwarze-Zander, Raphael Mohr
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Adult Male 0301 basic medicine Cart medicine.medical_specialty Human immunodeficiency virus (HIV) lcsh:Medicine HIV Infections Viremia medicine.disease_cause DIRECT ACTING ANTIVIRALS Antiviral Agents Article Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans In patient Longitudinal Studies Viral hepatitis lcsh:Science Liver diseases Aged Multidisciplinary Coinfection Proportional hazards model business.industry lcsh:R virus diseases Middle Aged medicine.disease Hepatitis C Antiretroviral therapy 030104 developmental biology Anti-Retroviral Agents Cohort Infectious diseases Female lcsh:Q business 030217 neurology & neurosurgery
Zdroj:	Scientific Reports, Vol 9, Iss 1, Pp 1-9 (2019) Scientific Reports
ISSN:	2045-2322
Popis:	HIV/HCV infection is supposed to substantially reduce survival as compared to HIV mono-infection. Here, we compared longtime-survival and causes of death in a cohort of HIV- and HIV/HCV-co-infected patients on combined antiretroviral therapy (cART), before introduction of HCV direct acting antivirals (DAA). 322 Caucasian patients with HIV (n = 176) and HIV/HCV-infection (n = 146) were enrolled into this study. All patients were recruited between 2003 and 2004 and followed until 01.01.2014. We compared overall survival between the two groups by the Kaplan-Meyer method and identified independent factors associated with long-time survival by conditional Cox regression analysis. In total 46 (14.3%) patients died during the observation period (HIV infection: n = 23 (13.1%), HIV/HCV infection: n = 23 (15.8%) but overall-survival did not differ significantly between HIV/HCV-infected and HIV mono-infected patients (p = 0.619). Survival was substantially better in patients with complete suppression of HIV replication below the level of detection than in those with residual viremia (p = 0.001). Age (p = 0.008), γ-glutamyltranspeptidase (p
Databáze:	OpenAIRE
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