The N-terminal pro brain natriuretic peptide is the best predictor of mortality during hospitalization in patients with low risk of sepsis-related organ failure
| Autor: | Irene Marín, Eva García Villalba, Angeles Muñoz, Mari Paz Egea, Enrique Bernal Morell, Alfredo Cano Sanchez, Jose Miguel Gomez Verdu, Salvador Valero, Victoria Callejo Hurtado, Antonia Alcaraz Garcia, Angela Santo, MariCarmen Vera, Monica Martinez |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Calcitonin Male medicine.medical_specialty Organ Dysfunction Scores Multiple Organ Failure Procalcitonin Sepsis 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Natriuretic Peptide Brain Medicine Humans Clinical severity In patient 030212 general & internal medicine Hospital Mortality Prospective Studies Intensive care medicine Aged Aged 80 and over business.industry 030208 emergency & critical care medicine Middle Aged medicine.disease Prognosis Peptide Fragments Clinical Practice C-Reactive Protein ROC Curve Area Under Curve Observational study SOFA score Female business hormones hormone substitutes and hormone antagonists N-terminal pro-Brain Natriuretic Peptide Biomarkers |
| Zdroj: | Medicina clinica. 149(5) |
| ISSN: | 1578-8989 |
| Popis: | The purpose of this study was to investigate the value of N-terminal pro brain natriuretic peptide (NT-proBNP), C-reactive protein (CRP) and procalcitonin (PCT) in predicting mortality in septic patients during hospitalization with mortality risk10% evaluated by Sepsis-related Organ Failure Assessment (SOFA).Prospective, observational study performed in sepsis patients with SOFA risk10%. We obtained levels of biomarkers in the first 72h after admission in hospital. All patients were monitored during hospitalization or until death. We used ROC curves to determine area under curve (AUC) and identify the best cutoff concentrations to predict mortality.A total of 174 patients were analyzed. Seventeen (9.8%) patients died during hospitalization. The AUC of NT-proBNP was 0.793 (95% CI 0.686-0.9; P.0005) compared to AUC of CRP (0.728; 95% CI 0.617-0.839; P=.004) and AUC of PCT (0.684; 95% CI 0.557-0.811; P=.019). Factors independently associated with in-hospital mortality were NT-proBNP1,330pg/ml (OR=23.23; 95% CI 2.92-182.25; P=.003) and to have predisposing factors (OR=3.05; 95% CI 1.3-9.3; P=.044) CONCLUSIONS: In patients with low mortality risk according to SOFA score, NT-proBNP obtained in the first 72h after admission prove to be a powerful predictor of mortality. Their implementations in clinical practice would improve the predictive ability of clinical severity scores. |
| Databáze: | OpenAIRE |
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