Antibacterial kaneoheoic acids A-F from a Hawaiian fungus Fusarium sp. FM701
| Autor: | Zhenquan Hu, Shaobin Hou, Shugeng Cao, Jennifer Saito, Kirk E. Hevener, John N. Alumasa, KH Ahammad Uz Zaman, Xiaohua Wu, Wesley Y. Yoshida, Kristiana A Avad |
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| Rok vydání: | 2021 |
| Předmět: |
0106 biological sciences
Fusarium Circular dichroism medicine.drug_class Antibiotics Microbial Sensitivity Tests Plant Science Bacillus subtilis Fungus Horticulture medicine.disease_cause 01 natural sciences Biochemistry Hawaii Article Microbiology medicine Molecular Biology biology 010405 organic chemistry Chemistry Chloramphenicol Fungi General Medicine biology.organism_classification Anti-Bacterial Agents 0104 chemical sciences Staphylococcus aureus Polyketides Antibacterial activity 010606 plant biology & botany medicine.drug |
| Zdroj: | Phytochemistry |
| ISSN: | 0031-9422 |
| DOI: | 10.1016/j.phytochem.2020.112545 |
| Popis: | Alarming rate of resistance to the existing antibiotics exhibits the importance of developing new antibiotic molecules from relatively under explored sources as well as implementing alternative approaches like antibiotic adjuvants. Six previously undescribed fungal polyketides, kaneoheoic acids A-F (1–6) were isolated from a fungal strain Fusarium sp. FM701 which was collected from a muddy sample of Hawaiian beach. The structures of these six compounds were elucidated by spectroscopic interpretation, including HRESIMS and NMR, and electronic circular dichroism (ECD) analysis. All six compounds that were inactive when tested alone showed significant antibacterial activity against Staphylococcus aureus and Bacillus subtilis, in the range of 10–80 μg/mL when assayed in combination with either chloramphenicol (half of the MIC, 1 μg/mL), an FDA approved antibiotic or disulfiram (6 μg/mL), an established antibiotic adjuvant that augmented the activity of antibiotics. |
| Databáze: | OpenAIRE |
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