Early lymphocyte recovery is an important determinant of outcome following allogeneic transplantation with CD34+ selected graft and limited T-cell addback
| Autor: | Martin G Guttridge, Derwood Pamphilon, Alan Lankester, J Brown, David I. Marks, Suparno Chakrabarti |
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| Rok vydání: | 2003 |
| Předmět: |
Adult
Male medicine.medical_specialty Allogeneic transplantation Lymphocyte Transfusion CD3 Complex Lymphocyte T cell CD34 Graft vs Host Disease Antigens CD34 Pilot Projects Opportunistic Infections Gastroenterology Recurrence Internal medicine medicine Humans Transplantation Homologous Survival analysis Probability Transplantation Peripheral Blood Stem Cell Transplantation business.industry Lymphopoiesis Hematology Middle Aged medicine.disease Survival Analysis Surgery Graft-versus-host disease medicine.anatomical_structure Treatment Outcome Hematologic Neoplasms Female business Follow-Up Studies |
| Zdroj: | Bone marrow transplantation. 32(1) |
| ISSN: | 0268-3369 |
| Popis: | We evaluated the outcome of 29 patients (age 22-60 years), who received a CD34+selected related (n=16) or unrelated graft (n=13) with limited T-cell addback (TCAB) (median 5.9 x 10(4)/kg) following full-intensity conditioning for haematological malignancies. In all, 16 patients (55%) had either advanced disease or previous transplants. The cumulative incidences of grade 2-4 acute GVHD were 15.4 and 19.2% and that for chronic extensive GVHD were 35 and 37% in related and unrelated graft recipients, respectively. The strongest predictor of nonrelapse mortality and overall survival was the absolute lymphocyte count (ALC) at 30 days; patients with ALC |
| Databáze: | OpenAIRE |
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