Neuron class-specific responses govern adaptive myelin remodeling in the neocortex
| Autor: | Katrin Michel, Sung Min Yang, Paola Arlotta, Elly Nedivi, Vahbiz Jokhi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Sensory system Mice Transgenic Neocortex Biology Inhibitory postsynaptic potential Corpus Callosum 03 medical and health sciences Myelin Mice 0302 clinical medicine Interneurons Neuroplasticity medicine Animals GABAergic Neurons Myelin Sheath Visual Cortex Neurons Multidisciplinary Neuronal Plasticity Molecular Imaging Mice Inbred C57BL Monocular deprivation 030104 developmental biology Visual cortex medicine.anatomical_structure Parvalbumins nervous system Female Neuron Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | PMC |
| ISSN: | 1095-9203 |
| Popis: | Cellular effects of visual deprivation Myelination speeds the progress of action potentials along neuronal axons. Yang et al. studied changes in myelination in the mouse visual cortex in response to visual experience (see the Perspective by Yalçin and Monje). With normal vision, myelination is continuously remodeled. As ocular dominance shifts in response to monocular deprivation, myelination patterns change on certain inhibitory interneurons but not on excitatory callosal projection neurons. Myelin sheaths are both added and subtracted, segments of myelin elongate and contract, and preexisting oligodendrocytes make new myelin sheaths. This adaptive myelination helps to diversify neuronal function and remodel neuronal circuits in response to sensory experience. Science , this issue p. eabd2109 ; see also p. 1414 |
| Databáze: | OpenAIRE |
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