Night Shift Work Affects Urine Metabolite Profiles of Nurses with Early Chronotype
| Autor: | Thomas Kantermann, Thomas Behrens, Jerzy Adamski, Hannelore Daniel, Volker Harth, Thomas Brüning, Rui Wang-Sattler, Dirk Pallapies, Martin Hrabé de Angelis, Martina Troll, Heiko Lickert, Sylvia Rabstein, Markus Rotter, Erik Bader, Katarzyna Burek, Thomas Illig, Jonathan Adam, Marcela Covic, Hans J. Grabe, Cornelia Prehn, Birgit Rathkolb, Stefan Brandmaier, Johannes Hertel |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Metabolite chronotypes lcsh:QR1-502 Physiology Urine Biochemistry lcsh:Microbiology 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine urine normalization Medicine night shift work Molecular Biology Creatinine business.industry Chronotype metabolomics 030104 developmental biology chemistry women’s’ health ddc:540 Mixed effects business Long chain 030217 neurology & neurosurgery Night Shift Work Targeted metabolomics |
| Zdroj: | Metabolites 8(3), 45 (2018). doi:10.3390/metabo8030045 Metabolites Volume 8 Issue 3 Metabolites, Vol 8, Iss 3, p 45 (2018) |
| DOI: | 10.3390/metabo8030045 |
| Popis: | Night shift work can have a serious impact on health. Here, we assess whether and how night shift work influences the metabolite profiles, specifically with respect to different chronotype classes. We have recruited 100 women including 68 nurses working both, day shift and night shifts for up to 5 consecutive days and collected 3640 spontaneous urine samples. About 424 waking-up urine samples were measured using a targeted metabolomics approach. To account for urine dilution, we applied three methods to normalize the metabolite values: creatinine-, osmolality- and regression-based normalization. Based on linear mixed effect models, we found 31 metabolites significantly (false discovery rate < 0.05) affected in nurses working in night shifts. One metabolite, acylcarnitine C10:2, was consistently identified with all three normalization methods. We further observed 11 and 4 metabolites significantly associated with night shift in early and late chronotype classes, respectively. Increased levels of medium- and long chain acylcarnitines indicate a strong impairment of the fatty acid oxidation. Our results show that night shift work influences acylcarnitines and BCAAs, particularly in nurses in the early chronotype class. Women with intermediate and late chronotypes appear to be less affected by night shift work. |
| Databáze: | OpenAIRE |
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