Molecular mechanism of prion-like tau-induced neurodegeneration
| Autor: | Christopher P. Corbo, Leah S. Cohen, Cindy Beharry, Alejandra del C. Alonso |
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| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Epidemiology Hyperphosphorylation tau Proteins Biology Microtubules Prion Diseases 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Developmental Neuroscience Microtubule Alzheimer Disease mental disorders medicine Animals Humans Phosphorylation Actin Health Policy Neurodegeneration medicine.disease Actin cytoskeleton Cell biology Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Tauopathies Neurology (clinical) Geriatrics and Gerontology Alzheimer's disease Nucleus Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer'sdementia : the journal of the Alzheimer's Association. 12(10) |
| ISSN: | 1552-5279 |
| Popis: | Introduction Accumulation of hyperphosphorylated tau and the disruption of microtubules are correlated with synaptic loss and pathology of Alzheimer's disease (AD). Impaired cognitive function and pathology of AD is correlated with this lesion. This review looks at the mechanism of neurodegeneration, the prion-like behavior of tau in its interaction with normal MAPs in correlation with tau hyperphosphorylation. Methods We reviewed our work in the field as well as current literature that pertains to tau phosphorylation and the biological effects. Results Hyperphosphorylation of tau in AD, in vitro, in cells, or in animal models converts this protein into a prion-like protein that is able to propagate the altered conformation. Discussion These findings suggest that phosphorylation of tau is a critical event in neurodegeneration. The combination of phosphorylation sites can generate a gain of toxic function for tau. The mechanism of tau toxicity might involve not only the microtubule system but also interference with other cellular compartments such as the nucleus and the actin cytoskeleton. |
| Databáze: | OpenAIRE |
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