Healing of chronic wounds : an update of recent developments and future possibilities
| Autor: | Kee Woei Ng, Kara L. Spiller, May Win Naing, Wai Yee Yeong, Wei Long Ng, Mark Van Dyke, Mustafa Hussain Kathawala, Dan Liu |
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| Přispěvatelé: | School of Materials Science and Engineering, School of Mechanical and Aerospace Engineering, Environmental Chemistry & Materials Centre, Nanyang Environment and Water Research Institute, Singapore Centre for 3D Printing, Singapore Institute of Manufacturing Technology |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0206 medical engineering
Biomedical Engineering Bioengineering Biocompatible Materials 02 engineering and technology Biologics Biochemistry Biomaterials Medicine Animals Humans Healing wounds Skin Wound Healing integumentary system Tissue Engineering Materials [Engineering] business.industry 021001 nanoscience & nanotechnology 020601 biomedical engineering Review article Clinical Practice Wound management Chronic Disease Wounds and Injuries Engineering ethics 0210 nano-technology business |
| Popis: | Chronic wounds are the result of disruptions in the body's usual process of healing. They are not only a source of significant pain and discomfort but also, more importantly, an unguarded port of entry for pathogens into the body. While our current understanding of this phenomenon is far from complete, findings in physiological patterns and advancements in wound healing technologies have helped develop wound management and healing solutions to this long-standing medical challenge. This review presents an overview of known wound healing mechanics, abnormalities that lead to chronic wounds, and a summary of established and new wound healing technologies. Various approaches to heal wounds are discussed, from dermal replacements to advanced biomaterial-based treatments, from cell-, synthetic-, and composite-based approaches to preclinical approaches, which make developing such products possible. While tested breakthrough products are described, the authors focused more on recently developed innovations, which are at varying stages of maturity. The review concludes with a note on future perspectives and opinions on where the field and industry are headed and where they should be. Impact Statement Wound healing is an important area of research and clinical practice, and has captured the attention of tissue engineers since the nascent beginnings of the discipline. Tissue-engineered skin was the first FDA-approved product, achieved in 1996. Despite this success, and the passage of time, healing wounds, particularly chronic wounds, remains a vexing challenge. This comprehensive review article will provide readers with a synopsis of current issues, research approaches, animal models, technologies, and products that span the continuum from early development to clinical studies, in the hope of fueling new interests and ideas to overcome this long-standing medical challenge. |
| Databáze: | OpenAIRE |
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