Secondary antibody deficiency is associated with development of infection in kidney transplantation: Results of a multicenter study
| Autor: | Marisa Rodriguez-Ferrero, Sergio Mezzano, M. Jaramillo, Manuel Arias, Manel Perelló, F. Anaya, Daniel Seron, Joaquin Luis Navarro, Javier Carbone, Emilio Rodrigo, Elizabeth Sarmiento, Patricia Muñoz, Marisa di Natale, I. Ezzahouri, Alba Alarcon, L. Calahorra, Boris Karanovic, Maricela Jimenez, Marcos López-Hoyos |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
medicine.medical_specialty Congenital cytomegalovirus infection Cytomegalovirus 030230 surgery Gastroenterology Immunoglobulin G Hypogammaglobulinemia 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Prospective Studies Kidney transplantation Transplantation biology business.industry Antibody titer Odds ratio medicine.disease Kidney Transplantation Infectious Diseases Cytomegalovirus Infections biology.protein 030211 gastroenterology & hepatology Antibody business |
| Zdroj: | Transplant infectious disease : an official journal of the Transplantation SocietyREFERENCES. 23(2) |
| ISSN: | 1399-3062 |
| Popis: | BACKGROUND We performed a multicenter study to assess the association between secondary antibody deficiency (immunoglobulin G [IgG] hypogammaglobulinemia combined with low levels of specific antibodies) and development of infection in kidney transplantation. METHODS We prospectively analyzed 250 adult kidney recipients at four centers. The assessment points were before transplantation and 7 and 30 days after transplantation. The immune parameters were as follows: IgG, IgA, and IgM and complement factors C3 and C4 tested by nephelometry; specific IgG antibodies to cytomegalovirus (CMV) and IgG and IgG2 antibodies to pneumococcal polysaccharide (anti-PPS) determined using enzyme-linked immunosorbent assay. The clinical follow-up period lasted 6 months. The clinical outcomes were CMV disease and recurrent bacterial infections requiring antimicrobial therapy. STATISTICS Multivariate logistic regression. RESULTS At day 7, IgG hypogammaglobulinemia (IgG levels |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text