Modelling flavoenzymatic charge transfer events: development of catalytic indole deuteration strategies
| Autor: | Paul R. Raithby, Alexander T. Murray, Jonathan D. Challinor, Christopher R. Pudney, Christina E. Gulácsy, David R. Carbery, Matthew P. John, Lauren E. Hatcher, Cristina Lujan |
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| Rok vydání: | 2016 |
| Předmět: |
Indole test
Models Molecular Indoles FMN Reductase 010405 organic chemistry Chemistry Organic Chemistry Kinetics Complex formation Cationic polymerization Charge (physics) Flavin group 010402 general chemistry Crystallography X-Ray Deuterium 01 natural sciences Biochemistry Catalysis Streptomyces 0104 chemical sciences Electron Transport Crystallography Flavins Physical and Theoretical Chemistry |
| Zdroj: | Organicbiomolecular chemistry. 14(15) |
| ISSN: | 1477-0539 |
| Popis: | The formation and chemistry of flavin–indole charge transfer (CT) complexes has been studied using a model cationic flavin. The ability to form a CT complex is sensitive to indole structure as gauged by spectroscopic, kinetics and crystallographic studies. Single crystals of sufficient quality of a flavin–indole CT complex, suitable for X-ray diffraction, have been grown, allowing solid-state structural analysis. When CT complex formation is conducted in d4-methanol, an efficient and synthetically useful C-3 indole deuteration is observed. |
| Databáze: | OpenAIRE |
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