Association of Influenza Vaccination and Prognosis in Patients Testing Positive to SARS-COV-2 Swab Test: A Large-Scale Italian Multi-Database Cohort Study
| Autor: | Michele Ercolanoni, Marco Massari, Francesca R. Poggi, Massimo Fabiani, Claudia Bartolini, Gianluca Trifirò, Flavia Riccardo, Paolo Giorgi-Rossi, Olivia Leoni, Nicoletta Luxi, Ursula Kirchmayer, Valeria Belleudi, Rosa Gini, Filippo Da-Re, Pamela Mancuso, Stefania Spila-Alegiani, Stefano Guzzinati, Francesca Menniti-Ippolito |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Influenza vaccine Immunology Population COVID-19 Italy health database influenza vaccine prognosis Article law.invention 03 medical and health sciences 0302 clinical medicine law Internal medicine Drug Discovery Pandemic medicine Pharmacology (medical) 030212 general & internal medicine education Pharmacology education.field_of_study business.industry Intensive care unit Test (assessment) Vaccination 030104 developmental biology Infectious Diseases Relative risk Medicine business Cohort study |
| Zdroj: | Vaccines Volume 9 Issue 7 Vaccines, Vol 9, Iss 716, p 716 (2021) |
| ISSN: | 2076-393X |
| DOI: | 10.3390/vaccines9070716 |
| Popis: | To investigate the association of the 2019–2020 influenza vaccine with prognosis of patients positive for SARS-CoV-2A, a large multi-database cohort study was conducted in four Italian regions (i.e., Lazio, Lombardy, Veneto, and Tuscany) and the Reggio Emilia province (Emilia-Romagna). More than 21 million adults were residing in the study area (42% of the population). We included 115,945 COVID-19 cases diagnosed during the first wave of the pandemic (February–May, 2020) 34.6% of these had been vaccinated against influenza. Three outcomes were considered: hospitalization, death, and intensive care unit (ICU) admission/death. The adjusted relative risk (RR) of being hospitalized in the vaccinated group when compared with the non-vaccinated group was 0.87 (95% CI: 0.86–0.88). This reduction in risk was not confirmed for death (RR = 1.04 95% CI: 1.01–1.06), or for the combined outcome of ICU admission or death. In conclusion, our study, conducted on the vast majority of the population during the first wave of the pandemic in Italy, showed a 13% statistically significant reduction in the risk of hospitalization in some geographical areas and in the younger population. No impact of seasonal influenza vaccination on COVID-19 prognosis in terms of death and death or ICU admission was estimated. |
| Databáze: | OpenAIRE |
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