Correlations of programmed death 1 expression and serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic stem cell transplantation
| Autor: | Makoto Murata, Miho Murase, Tetsuya Nishida, Tomonori Kato, Tomoki Naoe, Yoshinori Ito |
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| Rok vydání: | 2014 |
| Předmět: |
Male
CMV pp65 Peptide medicine.medical_treatment Programmed Cell Death 1 Receptor Sialic Acid Binding Ig-like Lectin 3 Immunology CD33 Congenital cytomegalovirus infection Cytomegalovirus Gene Expression HLA-A24 Antigen Cell Communication Hematopoietic stem cell transplantation CD8-Positive T-Lymphocytes Cell Adhesion Immune Tolerance medicine Humans Transplantation Homologous Interleukin 6 biology Interleukin-6 business.industry Hematopoietic Stem Cell Transplantation virus diseases Middle Aged Viral Load medicine.disease Virology surgical procedures operative Cytomegalovirus Infections Host-Pathogen Interactions biology.protein Biomarker (medicine) Programmed death 1 business CD8 Signal Transduction |
| Zdroj: | Cellular Immunology. 288:53-59 |
| ISSN: | 0008-8749 |
| DOI: | 10.1016/j.cellimm.2014.02.007 |
| Popis: | The effect of programmed death 1 (PD-1) on cytomegalovirus (CMV)-specific T cells has not been thoroughly examined. We evaluated the involvement of exhausted CMV-specific T cells in persistent CMV infection after allogeneic hematopoietic stem cell transplantation (HSCT). CMV-specific CD8+ T cells obtained from an HLA-A∗24:02-positive patient, who failed to eliminate CMV for more than 1 year after HSCT, responded poorly to CMV pp65 peptide and showed high PD-1 expression. Sera from patients with persistent CMV infection showed a significantly higher IL-6 level than those from patients with temporary CMV infection after allogeneic HSCT and healthy donors. CD33+ adherent cells produced IL-6, and regulated PD-1 expression and growth of CMV-specific CD8+ T cells through cell-to-cell contact. Although further investigation is required to clarify the association between IL-6 level and CMV infection in more patients, IL-6 might be a useful biomarker of persistent CMV infection after allogeneic HSCT. |
| Databáze: | OpenAIRE |
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