RNA-Mediated Therapeutics: From Gene Inactivation to Clinical Application
Autor: | Dimitra Kalavrizioti, Anastassios Vourekas, Stamatina Giannouli, Constantinos Stathopoulos, Chrisavgi Toumpeki, Denis Drainas, Vasiliki Stamatopoulou |
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Rok vydání: | 2006 |
Předmět: |
Genetics
biology Genomic data Cell Ribozyme RNA Context (language use) Genetic Therapy General Medicine Computational biology medicine.anatomical_structure RNA interference Drug Discovery Gene expression biology.protein medicine Animals Humans Gene Silencing Gene Randomized Controlled Trials as Topic |
Zdroj: | Current Topics in Medicinal Chemistry. 6:1737-1758 |
ISSN: | 1568-0266 |
Popis: | The specific targeting and inactivation of gene expression represents nowadays the goal of the mainstream basic and applied biomedical research. Both researchers and pharmaceutical companies, taking advantage of the vast amount of genomic data, have been focusing on effective endogenous mechanisms of the cell that can be used against abnormal gene expression. In this context, RNA represents a key molecule that serves both as tool and target for deploying molecular strategies based on the suppression of genes of interest. The main RNA-mediated therapeutic methodologies, deriving from studies on catalytic activity of ribozymes, blockage of mRNA translation and the recently identified RNA interference, will be discussed in an effort to understand the utilities of RNA as a central molecule during gene expression. |
Databáze: | OpenAIRE |
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