Mitomycin C in Combination with Orchiectomy for Newly Diagnosed Metastatic Prostate Cancer: Preliminary Results on a Randomized Trial
| Autor: | I. Billiet, Luc van Uytsel, Luc Baert, Jan Derluyn, Frank van den Broucke, Hein Van Poppel, Robert Paridaens, Guy Popelier, Jacques Casselman |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Mitomycin Urology medicine.medical_treatment law.invention Prostate cancer Randomized controlled trial Prostate law Carcinoma Humans Medicine Prospective Studies Orchiectomy Neoplasm Metastasis Prospective cohort study Aged Chemotherapy business.industry Mitomycin C Prostatic Neoplasms medicine.disease Combined Modality Therapy Surgery medicine.anatomical_structure business Follow-Up Studies |
| Zdroj: | Journal of Urology. 149:1485-1487 |
| ISSN: | 1527-3792 0022-5347 |
| DOI: | 10.1016/s0022-5347(17)36423-6 |
| Popis: | The preliminary results of a randomized trial comparing orchiectomy versus orchiectomy and mitomycin C in 119 newly diagnosed metastatic prostate cancer patients are presented. Of 109 evaluable patients 57 were treated with orchiectomy alone and 52 received adjuvant intravenous mitomycin C. Mean interval to progression was 13 months in the orchiectomy group versus 11 months in the mitomycin C group. Preliminary analysis did not demonstrate a favorable effect of the combination with this chemotherapeutic agent compared to orchiectomy alone (p = 0.3). |
| Databáze: | OpenAIRE |
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