Estimation of myocardial extracellular volume fraction with cardiac CT in subjects without clinical coronary artery disease: A feasibility study

Autor: Masaaki Ito, Shiro Nakamori, Yusuke Kurobe, Kaoru Dohi, Hiroshi Nakajima, Yoshie Kurita, Kakuya Kitagawa, Hajime Sakuma
Rok vydání: 2015
Předmět:
Male
Intraclass correlation
Computed Tomography Angiography
030204 cardiovascular system & hematology
030218 nuclear medicine & medical imaging
Coronary artery disease
03 medical and health sciences
Myocardial perfusion imaging
0302 clinical medicine
Sex Factors
Predictive Value of Tests
Hounsfield scale
medicine
Humans
Radiology
Nuclear Medicine and imaging
Computed tomography angiography
Aged
Observer Variation
medicine.diagnostic_test
business.industry
Myocardium
Age Factors
Myocardial Perfusion Imaging
Reproducibility of Results
Magnetic resonance imaging
Middle Aged
medicine.disease
Fibrosis
Extracellular Matrix
Predictive value of tests
Feasibility Studies
Radiographic Image Interpretation
Computer-Assisted
Myocardial fibrosis
Female
Cardiology and Cardiovascular Medicine
business
Nuclear medicine
Cardiomyopathies
Tomography
X-Ray Computed
Algorithms
Zdroj: Journal of cardiovascular computed tomography. 10(3)
ISSN: 1876-861X
Popis: Background Use of CT for assessment of extracellular volume fraction (ECV) is a new approach toward the evaluation of diffuse and focal myocardial fibrosis. It has recently been demonstrated that a hybrid algorithm of half- and full-scan reconstruction can improve image quality of delayed-phase CT. Objective The purpose of this study was to evaluate reproducibility of CT measurement of ECV of the myocardium using pre-contrast and delayed-phase CT, and to investigate the association between ECV and location, age and gender in subjects without clinical coronary artery disease. Methods Thirty-eight subjects (ages 45–78, mean 65 years, 14 females) without coronary artery stenosis, stress perfusion deficits or myocardial delayed enhancement on comprehensive cardiac CT comprise the study population. Delayed-phase CT was reconstructed with the hybrid algorithm. ECV was calculated as a ratio of the change in Hounsfield unit of the myocardium and the left ventricular (LV) blood before and after contrast administration, multiplied by (1 − hematocrit). Results Good inter- and intra-observer agreement was observed in CT measurement of ECV (intraclass correlation coefficient: 0.968 and 0.971, respectively). Mean ECV was 26.1 ± 2.0% (range 22.6–30.0%), and was positively related to age (r = 0.46, p = 0.003). Mean ECV in males was lower compared with females (25.5 ± 2.0% vs. 27.1 ± 1.8%, p = 0.02). There was no statistically significant difference in ECV between anterior, septal, inferior, and lateral segments. Conclusions CT measurement of myocardial ECV showed high inter- and intra-observer reproducibility, and age-related increase and gender-related difference of ECV were demonstrated. This might enable additional CT evaluation of diffuse and focal myocardial fibrosis in various pathological conditions as part of a comprehensive cardiac CT examination.
Databáze: OpenAIRE
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