Type I collagen gene regulation and the molecular pathogenesis of cirrhosis
| Autor: | M. Breindl, David A. Brenner, J. Westwick |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Liver Cirrhosis
medicine.medical_specialty Transcription Genetic Physiology Biology Liver Cirrhosis Experimental Collagen receptor Extracellular matrix Physiology (medical) Internal medicine Gene expression medicine Animals Humans Gene Regulation of gene expression Hepatology Gastroenterology Exons Introns Chromatin Cell biology Endocrinology Gene Expression Regulation DNA methylation Collagen Type I collagen Transcription Factors |
| Zdroj: | Scopus-Elsevier |
| ISSN: | 1522-1547 0193-1857 |
| Popis: | Cirrhosis is characterized by an increased deposition of extracellular matrix proteins, including type I collagen. Type I collagen is a product of two genes, alpha 1(I) and alpha 2(I), which are generally coordinately regulated. Since expression of type I collagen genes is increased during cirrhosis, understanding the structure and function of the regulatory components of the type I collagen genes should provide insight into the molecular pathogenesis of cirrhosis. This review will analyze the collagen alpha 1(I) gene with respect to chromatin structure, DNA methylation, regulation by agonists, and DNA-protein interactions. |
| Databáze: | OpenAIRE |
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