| Autor: |
Guzal Khayrullina, Moritz, Kasey E., Schooley, James F., Fatima, Naheed, Viollet, Coralie, McCormack, Nikki M., Smyth, Jeremy T., Doughty, Martin L., Dalgard, Clifton L., Flagg, Thomas P., Burnett, Barrington G. |
| Rok vydání: |
2020 |
| DOI: |
10.6084/m9.figshare.12276782.v1 |
| Popis: |
Additional file 1:Supplemental Figure 1. Elevated expression of ANP in SMA model mice. qRT-PCR analysis of ANP mRNA expression. Expression levels (mean ± SEM) in SMN-deficient (SMA) heart tissue are represented relative to unaffected controls at each time point. Statistical analysis: p values shown for one-way ANOVA, Tukey’s post hoc. Supplemental Figure 2. Serca2 levels reduced in cardiomyocytes derived from SMN-deficient iPSCs. Expression of SERCA2a expression was determined in control and SMN-deficient iPSC-derived cardiomyocytes. Cells were transfected with siRNA targeting SMN on day 18 of differentiation and qRT-PCR performed 48 hours after transfection. Values represent mean ± SEM. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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