An investigation of vancomycin minimum inhibitory concentration creep among methicillin-resistant Staphylococcus aureus strains isolated from pediatric patients and healthy children in Northern Taiwan
| Autor: | Ching-Mei Yu, Chia-Ning Chang, Ming-Chin Chan, Chih-Chien Wang, Wen-Tsung Lo |
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| Jazyk: | angličtina |
| Předmět: |
0301 basic medicine
Male Meticillin lcsh:QR1-502 medicine.disease_cause lcsh:Microbiology Tertiary Care Centers Immunology and Allergy Child Vancomycin creep General Medicine Staphylococcal Infections Anti-Bacterial Agents Electrophoresis Gel Pulsed-Field Infectious Diseases Staphylococcus aureus Child Preschool Carrier State Vancomycin Female Methicillin-resistant Staphylococcus aureus medicine.drug Microbiology (medical) Adolescent Genotype 030106 microbiology Taiwan Microbial Sensitivity Tests Microbiology 03 medical and health sciences Minimum inhibitory concentration Daptomycin Immunology and Microbiology(all) medicine Pulsed-field gel electrophoresis Humans Etest Retrospective Studies General Immunology and Microbiology business.industry Infant Newborn Genetic Variation Infant biochemical phenomena metabolism and nutrition bacterial infections and mycoses Molecular Typing Pulsed-field gel electrophoresis type of MRSA business |
| Zdroj: | Journal of Microbiology, Immunology and Infection, Vol 50, Iss 3, Pp 362-369 (2017) |
| ISSN: | 1684-1182 |
| DOI: | 10.1016/j.jmii.2015.05.013 |
| Popis: | Background and purpose: The phenomenon of vancomycin minimum inhibitory concentration (MIC) creep is an increasingly serious problem in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infections. In this study, we investigated the vancomycin and daptomycin MIC values of MRSA strains isolated from pediatric patients and MRSA colonized healthy children. Then, we assessed whether there was evidence of clonal dissemination for strains with an MIC to vancomycin of ≥ 1.5 μg/mL. Methods: We collected clinical MRSA isolates from pediatric patients and from healthy children colonized with MRSA during 2008–2012 at a tertiary medical center in northern Taiwan and obtained vancomycin and daptomycin MIC values using the Etest method. Pulse-field gel electrophoresis (PFGE) and staphylococcal cassette chromosome (SCCmec) typing were used to assess clonal dissemination for strains with an MIC to vancomycin of ≥ 1.5 μg/mL. Results: A total 195 MRSA strains were included in this study; 87 were isolated patients with a clinical MRSA infection, and the other 108 strains from nasally colonized healthy children. Vancomycin MIC≥1.5 μg/mL was seen in more clinical isolates (60/87, 69%) than colonized isolates (32/108, 29.6%), p |
| Databáze: | OpenAIRE |
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