Racial and Ethnic Variation in Time to Prostate Biopsy After an Elevated Screening Level of Serum Prostate-specific Antigen
| Autor: | Stephanie R. Reading, Ronald K. Loo, Steven J. Jacobsen, Lauren P. Wallner, Jin Wen Y Hsu, Kimberly R. Porter |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Prostate biopsy Biopsy Urology 030232 urology & nephrology Prostatitis 03 medical and health sciences Prostate cancer 0302 clinical medicine Prostate Internal medicine Ethnicity medicine Humans Aged Retrospective Studies Gynecology medicine.diagnostic_test business.industry Racial Groups Hazard ratio Prostatic Neoplasms Middle Aged Patient Acceptance of Health Care Prostate-Specific Antigen medicine.disease Prostate-specific antigen medicine.anatomical_structure 030220 oncology & carcinogenesis Pacific islanders business |
| Zdroj: | Urology. 96:121-127 |
| ISSN: | 0090-4295 |
| DOI: | 10.1016/j.urology.2016.06.008 |
| Popis: | Objective To examine the racial and ethnic variation in time to prostate biopsy after an elevated screening level of serum prostate-specific antigen (PSA). Methods Male members of the Kaiser Permanente of Southern California health plan, 45 years of age or older, with no history of prostate cancer or a prostate biopsy, and at least 1 elevated screening level of serum PSA between January 1, 1998 and December 31, 2007 were retrospectively identified (n = 59,506). All participants were passively followed via electronic health records until their time of prostate biopsy, death, membership disenrollment, or study conclusion (December 31, 2014), whichever was the initial event. Proportional hazard regression analyses were used to estimate the association between time from an elevated screening level of serum PSA to prostate biopsy, adjusting for age, benign prostatic hyperplasia, prostatitis, type 2 diabetes mellitus, hypertension, and Charlson Comorbidity Index score. Results Median time until biopsy was 0.6 years (214 days), with approximately 41% of participants receiving a prostate biopsy within the study period. Results from the fully adjusted analysis indicated that the non-Hispanic Asian or Pacific Islanders (hazard ratio: 1.10, 95% confidence interval: [1.04, 1.15]) and the non-Hispanic blacks (hazard ratio: 1.04, 95% confidence interval: [1.00, 1.08]) had a slightly shorter time to prostate biopsy after an elevated screening level of serum PSA compared to the non-Hispanic whites. Conclusion These data suggest that, within an integrated healthcare organization, minimal differences exist between racial and ethnic subgroups in their time to prostate biopsy after an elevated screening level of serum PSA. |
| Databáze: | OpenAIRE |
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