HYPERFRACTIONATED SPLIT-COURSE THORACIC RADIATION-THERAPY PLUS CHEMOTHERAPY IN LOCALLY ADVANCED NONSMALL CELL LUNG-CANCER

Autor:	Paolo Muto, A. Tortoriello, G. Facchini, Giancarlo Panelli, G. Frasci, Vincenzo Ravo, Rosario Vincenzo Iaffaioli, Francesco Caponigro
Rok vydání:	1994
Předmět:	Oncology Cancer Research medicine.medical_specialty Chemotherapy Performance status medicine.medical_treatment Cancer Biology medicine.disease Carboplatin Radiation therapy chemistry.chemical_compound chemistry Internal medicine medicine Lung cancer Survival rate Etoposide medicine.drug
Zdroj:	ResearcherID Europe PubMed Central
ISSN:	1791-2423 1019-6439
DOI:	10.3892/ijo.4.3.577
Popis:	Hyperfractionated split course radiotherapy combined with carboplatin, etoposide and mitomycin C was administered to 76 patients with stage III non-small cell lung cancer. Grade 4 leukopenia occurred in 5 patients; 4 toxic deaths were observed. The overall response rate was 45%, including a 9% rate of complete responses, which lasted > 12 months in four cases. The median survival was 13 months, 2-year progression-free survival 17%, actuarial 2-year survival rate 22%. Age > 65, performance status > 1, no response to prior treatment were predictors of poor outcome. Our treatment plan, particularly because of the long lasting complete responses, warrants further investigation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee482e63b6eea7f3ee81512b55972030 https://doi.org/10.3892/ijo.4.3.577 Zobrazit plný text záznamu