Actives from MMV Open Access Boxes? A suggested way forward

Autor: Jeremy N. Burrows, Benoît Laleu, Kirandeep Samby, Paul Willis, Peter J. H. Webborn
Rok vydání: 2021
Předmět:
Review
Validation Studies as Topic
Toxicology
Pathology and Laboratory Medicine
Medical Conditions
0302 clinical medicine
Drug Metabolism
Drug Discovery
Medicine and Health Sciences
Biology (General)
Marketing
health care economics and organizations
High rate
0303 health sciences
Cytotoxicity Assay
Neglected Diseases
Identification (information)
Infectious Diseases
Neglected Tropical Diseases
2019-20 coronavirus outbreak
Drug Research and Development
QH301-705.5
030231 tropical medicine
Immunology
Microbiology
Access to Information
03 medical and health sciences
Tropical Medicine
Virology
Parasitic Diseases
Genetics
medicine
Humans
Pharmacokinetics
Molecular Biology
030304 developmental biology
Pharmacology
Drug Screening
Poverty
Biology and Life Sciences
Tropical disease
RC581-607
Tropical Diseases
medicine.disease
Malaria
Intervention (law)
Workflow
Capacity strengthening
Parasitology
Immunologic diseases. Allergy
Zdroj: PLoS Pathogens, Vol 17, Iss 4, p e1009384 (2021)
PLoS Pathogens
ISSN: 1553-7374
Popis: It is estimated that more than 1 billion people across the world are affected by a neglected tropical disease (NTD) that requires medical intervention. These diseases tend to afflict people in areas with high rates of poverty and cost economies billions of dollars every year. Collaborative drug discovery efforts are required to reduce the burden of these diseases in endemic regions. The release of “Open Access Boxes” is an initiative launched by Medicines for Malaria Venture (MMV) in collaboration with its partners to catalyze new drug discovery in neglected diseases. These boxes are mainly requested by biology researchers across the globe who may not otherwise have access to compounds to screen nor knowledge of the workflow that needs to be followed after identification of actives from their screening campaigns. Here, we present guidelines on how to move such actives beyond the hit identification stage, to help in capacity strengthening and enable a greater impact of the initiative.
Databáze: OpenAIRE
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