Oxidative Damage of Mussels Living in Seawater Enriched with Trace Metals, from the Viewpoint of Proteins Expression and Modification
| Autor: | Dimitrios L. Kalpaxis, Panagiota C. Giannopoulou, Georgia G Kournouto, Eleni Sazakli, George P. Dinos, Michalis Leotsinidis |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
mercury
animal structures cadmium Health Toxicology and Mutagenesis Protein Carbonylation chemistry.chemical_element Oxidative phosphorylation 010501 environmental sciences Toxicology lcsh:Chemical technology medicine.disease_cause 01 natural sciences Article protein carbonylation Oxidative damage 03 medical and health sciences translation factors Biomonitoring medicine biochemistry oxidative stress lcsh:TP1-1185 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences Cadmium Chemical Health and Safety biology fungi oxidative stress biomarkers biology.organism_classification Copper Mytilus Mercury (element) Trace (semiology) chemistry Bioaccumulation copper Environmental chemistry Toxicity Seawater Oxidative stress |
| Zdroj: | Toxics, Vol 8, Iss 89, p 89 (2020) Toxics Volume 8 Issue 4 |
| DOI: | 10.20944/preprints202009.0642.v1 |
| Popis: | The impact of metals bioaccumulation in marine organisms is a subject of intense investigation. This study was designed to determine the association between oxidative stress induced by seawater enriched with trace metals and protein synthesis using as a model the mussels Mytilus galloprovincialis. Mussels were exposed to 40 &mu g/L Cu, 30 &mu g/L Hg, or 100 &mu g/L Cd for 5 and 15 days, and the pollution effect was evaluated by measuring established oxidative biomarkers. The results showed damage on the protein synthesis machine integrity and specifically on translation factors and ribosomal proteins expression and modifications. The exposure of mussels to all metals caused oxidative damage that was milder in the cases of Cu and Hg and more pronounced for Cd. However, after prolonged exposure of mussels to Cd (15 days), the effects receded. These changes that perturb protein biosynthesis can serve as a great tool for elucidating the mechanisms of toxicity and could be integrated in biomonitoring programs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|