Association between alcohol consumption and serum paraoxonase and arylesterase activities: a cross-sectional study within the Bavarian population

Autor: Tobias Pischon, Achim Bub, Jakob Linseisen, Katharina Nimptsch, Carolina Schwedhelm
Rok vydání: 2016
Předmět:
0301 basic medicine
Adult
Male
Adolescent
Alcohol Drinking
Cross-sectional study
Population
Medicine (miscellaneous)
Physiology
Alcohol
030204 cardiovascular system & hematology
Severity of Illness Index
Arylesterase
03 medical and health sciences
chemistry.chemical_compound
Young Adult
0302 clinical medicine
Germany
Humans
ddc:610
Risk factor
education
Aged
Aged
80 and over
education.field_of_study
Nutrition and Dietetics
biology
business.industry
Aryldialkylphosphatase
Hepatitis
Alcoholic
Paraoxonase
Reproducibility of Results
Middle Aged
Nutrition Surveys
PON1
Ae Arylesterase
Bvsii Bavarian Food Consumption Survey Ii
Pon1 Paraoxonase
Alcohol Consumption
Arylesterase Activity
Paraoxonase Activity
Paraoxonase Enzyme
Biotechnology
Up-Regulation
030104 developmental biology
Cross-Sectional Studies
chemistry
Cardiovascular and Metabolic Diseases
biology.protein
Female
business
Carboxylic Ester Hydrolases
Biomarkers
Zdroj: Br. J. Nutr. 115, 730-736 (2016)
ISSN: 1475-2662
Popis: High alcohol consumption is an important risk factor for chronic disease and liver degeneration. Paraoxonase (PON1) and arylesterase (AE) are functions of the enzyme paraoxonase, which is synthesised by the liver. Paraoxonase circulates in plasma bound to HDL and hydrolyses lipid peroxides, protecting lipoproteins against oxidative modification. It has been shown that excessive alcohol consumption leads to a reduction of serum PON1 and AE activities; however, studies investigating the association with low and moderate alcohol consumption are scarce. We investigated the cross-sectional association between alcohol consumption and serum activities of PON1 and AE using data from the population-based Bavarian Food Consumption Survey II survey. PON1 and AE activities were quantified in serum samples of 566 male and female study participants (aged 18–80 years), and dietary intake including alcohol consumption was estimated from three 24-h dietary recalls. The association between alcohol consumption and PON1 and AE activities was analysed using linear regression, adjusted for age, sex and socio-economic status. There was no strong association between alcohol consumption and enzymatic activities of PON1 and AE in the Bavarian population. PON1 activity was seen to be lowest in non-drinkers (0 g/d) and highest in people who consumed 15·1–30 g of alcohol/d. AE activity increased across alcohol consumption categories, with a mean maximum difference of 14 U/ml (Pfor linear trend0·04). These associations were attenuated after adjustment for blood concentrations of HDL. The results of this study do not support the hypothesis that alcohol consumption is related to important alterations in PON1 and AE activities.
Databáze: OpenAIRE
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