Cardiac thrombotic stability determined by contrast-enhanced echocardiography: investigative protocol and preliminary results
Autor: | Xueying Tan, Ying Li, Xin Wang, Weidong Ren, Xiaona Yu, Yangjie Xiao |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Adult
Male medicine.medical_specialty Time Factors Heart Diseases Contrast Media 030204 cardiovascular system & hematology 03 medical and health sciences Young Adult 0302 clinical medicine Text mining Hardness Predictive Value of Tests Internal medicine Albumins Elastic Modulus medicine Humans Diseases of the circulatory (Cardiovascular) system cardiovascular diseases Thrombus Child Blood Coagulation Whole blood Angiology Aged Aged 80 and over Observer Variation Shear wave elastography Fluorocarbons business.industry Research Ultrasound Reproducibility of Results Thrombosis Middle Aged medicine.disease Prognosis Cardiac surgery Embolism Echocardiography RC666-701 Cardiology cardiovascular system Female Cardiology and Cardiovascular Medicine business 030217 neurology & neurosurgery |
Zdroj: | BMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-10 (2021) BMC Cardiovascular Disorders |
ISSN: | 1471-2261 |
Popis: | Objective This study’s intent was to test a new system for scoring cardiac thrombotic stability, based on contrast-enhanced ultrasound (CEUS). Methods We used human whole blood for an in vitro thrombotic model involving 1-h (T1h) and 7-day (T7d) subsets. The T1h group was monitored for 1 h continuously to observe for the formation of a new thrombus on the original thrombus base. Changes in thrombotic CEUS images, histologic features, and shear wave elastography were recorded over time. We also studied 28 patients diagnosed with cardiac thrombi, each examined by transthoracic echocardiography and CEUS.Thrombi were scored for substrate (Ts) and hardness (Th) based on the visualized degree of contrast penetration into the thrombi. Statistical analyses of Ts and Th reflected thrombolytic time and risk of embolism to other organs. Results Histologically, the loosely constructed ends of in vitro thrombi solidified over time. In addition, the average Young’s modulus of thrombi over time indicated a progressive increase in hardness. Contrast-enhancing agents were able to penetrate fresh, loose thrombi only, not chronic, stable thrombi. As Ts and Th increased, prolonged thrombolytic time and greater risk of embolism to other organs were apparent. Conclusions Our data suggest that this new CEUS scoring system correlates well with cardiac thrombotic hardness and the quality of its underlying substrate, serving to quantify thrombotic stability. |
Databáze: | OpenAIRE |
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