On the mechanism of a radiation-induced change in enzymic differentiation during development
| Autor: | L. V. Slozhenikina, L. P. Mikhailets, Ushakova Te, A. M. Kuzin, L. A. Fialkovskaya |
|---|---|
| Rok vydání: | 1983 |
| Předmět: |
Male
Radiation biology Mechanism (biology) Embryogenesis Tyrosine Transaminase Biophysics Rats Inbred Strains Organogenesis Embryo Mammalian Rats Tyrosine aminotransferase Radiation-Induced Change Liver Biochemistry Pregnancy Cyclic AMP Glucose-6-Phosphatase biology.protein Animals Female Irradiation Glucose 6-phosphatase General Environmental Science |
| Zdroj: | Radiation and Environmental Biophysics. 21:205-215 |
| ISSN: | 1432-2099 0301-634X |
| DOI: | 10.1007/bf01323411 |
| Popis: | In experiments on glucose-6-phosphatase and tyrosine aminotransferase it was shown that radiation induces changes in enzymic differentiation in perinatal rat liver. A study was made of the probable reasons for the observed changes. It was shown that the macromolecular system of the protein enzyme synthesis was not damaged by the radiation doses used. The observed decrease in glucose-6-phosphatase activity during late embryogenesis, after pre-irradiation at early organogenesis, is eliminated by administration of exogenous thyroxine. A radiation-induced rise in the tyrosine aminotransferase activity during the perinatal period correlated with the cyclic AMP system status. It is proposed that modification of enzymic differentiation after irradiation results from the change in the amount of inductors. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink