The influence of omega-3 supplementation on vitamin D levels in humans: a systematic review and dose-response meta-analysis of randomized controlled trials
| Autor: | Bander Yayha Otayf, Osama Alomar, Almuhannad Ali Qadri, Hany Salem, Mihnea-Alexandru Găman, Hamed Kord-Varkaneh, Shing Cheng Tan, Ismail A. Al-Badawi, Habeeb Alhabeeb, Ahmed Abu-Zaid |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
030309 nutrition & dietetics Gastroenterology Omega Industrial and Manufacturing Engineering law.invention 03 medical and health sciences 0404 agricultural biotechnology Randomized controlled trial law Internal medicine medicine Vitamin D and neurology Humans Vitamin D Randomized Controlled Trials as Topic 0303 health sciences business.industry Vitamins 04 agricultural and veterinary sciences General Medicine 040401 food science Meta-analysis Dietary Supplements business Food Science |
| Zdroj: | Critical Reviews in Food Science and Nutrition. 62:3116-3123 |
| ISSN: | 1549-7852 1040-8398 |
| Popis: | Inconsistencies exist with regard to the influence of omega-3 supplementation on 25-hydroxyvitamin D (25(OH)D) levels, which could be attributed to many factors, such as the duration and dose of omega-3 supplementation, and individuals' baseline 25(OH)D levels. Therefore, to address the inconsistencies, we conducted a systematic review and dose-response meta-analysis to accurately determine the effect of omega-3 supplementation on 25(OH)D levels in humans.We performed a comprehensive literature search in Web of Science, PubMed/Medline, Scopus, and Embase databases from inception up to January 2020. We included only randomized controlled trials (RCTs). We used weighted mean difference (WMD) with 95% confidence interval (CI) to assess the influence of omega-3 supplementation on serum 25(OH)D levels using the random-effects model.Our pooled results of 10 RCTs demonstrated an overall significant increase in 25(OH)D levels following omega-3 intake (WMD = 3.77 ng/ml, 95% CI: 1.29, 6.25). In addition, 25(OH)D levels were significantly increased when the intervention duration lasted8 weeks and when the baseline serum 25(OH)D level was ˂20 ng/ml. Moreover, omega-3 intake ≤1000 mg/day resulted in higher 25(OH)D levels compared to omega-3 intake1000 mg/day.In conclusion, omega-3 supplementation increased 25(OH)D concentrations, particularly with dosages ≤1000 mg/day and intervention durations8 weeks. |
| Databáze: | OpenAIRE |
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