Intermediate-term outcome of cryoballoon ablation of persistent atrial fibrillation and improvements in quality of life of patients
| Autor: | Daniel Mol, Anchee M. Boersma, Wouter R. Berger, Muchtiar Khan, Gijsbert S. de Ruiter, Geert-Jan P. Kimman, Joris R. de Groot, Jonas S. S. G. de Jong |
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| Přispěvatelé: | Graduate School, Cardiology, ACS - Heart failure & arrhythmias |
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Male
Medical Implants Clinical Research Design Science Cardiology Bioengineering Research and Analysis Methods Cryosurgery Veins Mathematical and Statistical Techniques Heart Conduction System Atrial Fibrillation Medicine and Health Sciences Humans Statistical Methods Cardiac Atria Aged Multidisciplinary Statistics Biology and Life Sciences Heart Middle Aged Survival Analysis Health Care Research Design Physical Sciences Catheter Ablation Quality of Life Cardiovascular Anatomy Engineering and Technology Blood Vessels Medicine Female Medical Devices and Equipment Anatomy Arrhythmia Mathematics Follow-Up Studies Research Article Biotechnology |
| Zdroj: | PLoS ONE, Vol 17, Iss 1, p e0261841 (2022) PLoS ONE, Vol 17, Iss 1 (2022) PLoS ONE PLoS ONE, 17(1 January):e0261841. Public Library of Science |
| ISSN: | 1932-6203 |
| Popis: | BackgroundClinical outcome of pulmonary vein isolation (PVI) has been predominantly focused on the reoccurrence of atrial fibrillation (AF) and the maintenance of sinus rhythm. However, there has been a limited intermediate follow-up on health-related quality-of-life (HRQoL) of patients. Given the relatively high recurrence rate of persistent AF after PVI treatment, it is important to follow up with clinical outcomes on symptom improvement as well as health-related quality-of-life. This study was designed to investigate the recurrence rate of atrial tachyarrhythmia (ATa), AF-related symptoms and HRQoL after PVI in patients with persistent AF who were treated with the second generation cryoballoon.MethodsTotal 148 patients participated in the study who were treated by PVI between 2013 and 2017 for persistent AF. All patients visited the out-patient clinic 2–5 years after PVI. During this visit all patients filled-out an AF Effect on Quality-of-life (AFEQT) questionnaire and a seven-day Holter was applied. All rhythm recordings acquired post ablation were collected and analysed, and the modified European Heart Rhythm Association score (mEHRA) scores were calculated before and after the ablation.ResultsThe average age of patients was 63±9 year old and 44 (27.9%) were female. Mean CHA2DS2VASc score was 1.9±1.4, and moderate and severe left atrial (LA) dilation was present in 53 (36.1%) and 15 (10.2%) patients, respectively. After a follow-up of 3.7±1.0 years, 81 (54.7%) patients had an ATa recurrence and 35 (23.6%) patients underwent a repeat LA ablation. However, the mEHRA score significantly improved in 80.4% of the patients (pConclusionsThere is a considerable ATa recurrence rate after PVI of persistent AF at intermediate-term follow-up. However, our data indicate that PVI significantly improved AF-related symptoms and resulted in a high HRQoL for 2–5 years in patients with persistent AF. |
| Databáze: | OpenAIRE |
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