Describing post-polio syndrome
| Autor: | M.P. Sáinz, E. Capdevilla, S. Laxe, E. Portell, B. Castaño, R. Pelayo |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Weakness Pediatrics education 03 medical and health sciences 0302 clinical medicine Post-polio syndrome Epidemiology Materials Chemistry medicine Outpatient clinic Humans Depression (differential diagnoses) Fatigue Retrospective Studies business.industry Retrospective cohort study medicine.disease Dysphagia Poliomyelitis Disease Progression Female Postpoliomyelitis Syndrome medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Neurologia (Barcelona, Spain). 37(5) |
| ISSN: | 2173-5808 |
| Popis: | Introduction Patients presenting sequelae of poliomyelitis may present new symptoms, known as post-polio syndrome (PPS). Objective To identify the clinical and functional profile and epidemiological characteristics of patients presenting PPS. Patients and methods We performed a retrospective study of 400 patients with poliomyelitis attended at the Institut Guttmann outpatient clinic, of whom 310 were diagnosed with PPS. We describe patients’ epidemiological, clinical, and electromyographic variables and analyse the relationships between age of poliomyelitis onset and severity of the disease, and between sex, age of PPS onset, and the frequency of symptoms. Results PPS was more frequent in women (57.7%). The mean age at symptom onset was 52.4 years, and was earlier in women. Age at primary infection > 2 years was not related to greater poliomyelitis severity. The frequency of symptoms was: pain in 85% of patients, loss of strength in 40%, fatigue in 65.5%, tiredness in 57.8%, cold intolerance in 20.2%, dysphagia in 11.7%, cognitive complaints in 9%, and depressive symptoms in 31.5%. Fatigue, tiredness, depression, and cognitive complaints were significantly more frequent in women. Fifty-nine percent of patients presented electromyographic findings suggestive of PPS. Conclusions While the symptoms observed in our sample are similar to those reported in the literature, the frequencies observed are not. We believe that patients’ clinical profile may be very diverse, giving more weight to such objective parameters as worsening of symptoms or appearance of weakness; analysis of biomarkers may bring us closer to an accurate diagnosis. |
| Databáze: | OpenAIRE |
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