Dietary arsenic supplementation induces oxidative stress by suppressing nuclear factor erythroid 2-related factor 2 in the livers and kidneys of laying hens
| Autor: | Wenfeng Ma, Yan Ma, Yizhen Shi, Q. J. Wu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Antioxidant Nrf2-Keap1 pathway NF-E2-Related Factor 2 Eggs Oviposition medicine.medical_treatment Glutathione reductase laying hen Kidney medicine.disease_cause Antioxidants Metabolism and Nutrition Superoxide dismutase Random Allocation 03 medical and health sciences chemistry.chemical_compound Internal medicine medicine Animals lcsh:SF1-1100 030304 developmental biology chemistry.chemical_classification 0303 health sciences Kelch-Like ECH-Associated Protein 1 biology Dietary Arsenic Glutathione peroxidase arsenic 0402 animal and dairy science 04 agricultural and veterinary sciences General Medicine Malondialdehyde Animal Feed 040201 dairy & animal science Diet Oxidative Stress Endocrinology Liver chemistry Dietary Supplements biology.protein Uric acid Female Animal Science and Zoology lcsh:Animal culture Chickens Oxidative stress |
| Zdroj: | Poultry Science Poultry Science, Vol 100, Iss 2, Pp 982-992 (2021) |
| ISSN: | 0032-5791 |
| Popis: | This study investigated the effects of dietary arsenic supplementation on laying performance, egg quality, hepatic and renal histopathology, and oxidative stress in the livers and kidneys of laying hens. Furthermore, the nuclear factor erythroid 2-related factor 2 (Nrf2)-Kelch-like ECH-associated protein 1 (Keap1) pathway was explored to reveal the molecular mechanism of the stress. Five hundred and twelve 40-week-old Hyline White laying hens were randomly allocated to 4 groups with 8 pens per group and 16 hens per pen. The doses of arsenic administered to the 4 groups were 0.95, 20.78, 40.67, and 60.25 mg/kg. The results revealed that dietary arsenic supplementation significantly reduced hen-day egg production (P |
| Databáze: | OpenAIRE |
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