Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice

Autor: Kristy L. Thomas, Callie L. Root, Jonathan M. Peterson
Rok vydání: 2021
Předmět:
Male
Physiology
Gene Expression
Social Sciences
Biochemistry
Mice
Immune Physiology
Medicine and Health Sciences
Psychology
Innate Immune System
Multidisciplinary
Alcohol Consumption
Organic Compounds
Genetically Modified Organisms
Liver Diseases
Lipids
Addicts
Chemistry
Liver
Tumor Necrosis Factors
Physical Sciences
Medicine
Engineering and Technology
Hyperexpression Techniques
Cytokines
Female
Adiponectin
Genetic Engineering
Fatty Liver
Alcoholic
Research Article
Biotechnology
Science
Immunology
Addiction
Mice
Transgenic
Bioengineering
Gastroenterology and Hepatology
Diet
High-Fat
Research and Analysis Methods
Adipokines
Gene Expression and Vector Techniques
Animals
Obesity
Alcoholics
Molecular Biology Techniques
Molecular Biology
Nutrition
Molecular Biology Assays and Analysis Techniques
Ethanol
Genetically Modified Animals
Organic Chemistry
Chemical Compounds
Biology and Life Sciences
Molecular Development
Lipid Metabolism
Diet
Fatty Liver
Mice
Inbred C57BL
Alcohols
Immune System
Developmental Biology
Zdroj: PLoS ONE
PLoS ONE, Vol 17, Iss 1, p e0258557 (2022)
ISSN: 1932-6203
Popis: Alcoholic liver disease (ALD) is one of the leading causes of morbidity and mortality from hepatic complications. C1q/TNF-related protein 3 (CTRP3) is an adiponectin paralog and, in male mice, increased levels of circulating CTRP3 prevents ALD. Therefore, the purpose of this study was to replicate the observed hepatoprotective effect of elevated circulating CTRP3 levels in female mice. Twelve-week-old female wildtype and CTRP3 overexpressing transgenic mice were fed the Lieber-DeCarli alcohol-containing liquid diet (5% vol/vol) for 6 weeks. Unlike the previous study with male mice, CTRP3 overexpression provided no attenuation to alcohol-induced hepatic lipid accumulation, cytokine production, or overall mortality. In conclusion, there appears to be a clear sex-specific effect of CTRP3 in response to alcohol consumption that needs to be explored further.
Databáze: OpenAIRE
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