Effect of statins on atherogenic serum amyloid A and α1-antitrypsin low-density lipoprotein complexes

Autor: Yusuke Miyazaki, Yasufumi Katanasaka, Sae Hirano-Sunagawa, Masafumi Funamoto, Yoichi Sunagawa, Maki Komiyama, Noriko Satoh-Asahara, Akira Shimatsu, Eriko Morimoto, Hajime Yamakage, Koji Hasegawa, Hiromichi Wada, Tatsuya Morimoto
Rok vydání: 2016
Předmět:
0301 basic medicine
Adult
Male
medicine.medical_specialty
030204 cardiovascular system & hematology
Reductase
Coronary artery disease
03 medical and health sciences
chemistry.chemical_compound
Ventricular Dysfunction
Left
0302 clinical medicine
Internal medicine
medicine
Humans
Rosuvastatin
Serum amyloid A
Rosuvastatin Calcium
Pitavastatin
Aged
Dyslipidemias
Aged
80 and over
Serum Amyloid A Protein
business.industry
Middle Aged
medicine.disease
Atherosclerosis
Lipoproteins
LDL
030104 developmental biology
Endocrinology
Treatment Outcome
chemistry
Low-density lipoprotein
alpha 1-Antitrypsin
Quinolines
lipids (amino acids
peptides
and proteins)
Female
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Cardiology and Cardiovascular Medicine
business
Dyslipidemia
Biomarkers
medicine.drug
Lipoprotein
Follow-Up Studies
Zdroj: International journal of cardiology. 225
ISSN: 1874-1754
Popis: Purpose HMG-CoA reductase inhibitors, also termed statins, are used to reduce the risk of coronary artery disease. Two oxidatively modified low-density lipoprotein (LDL) complexes, serum amyloid A-LDL (SAA-LDL) and α1-antitrypsin-LDL (AT-LDL), serve as atherosclerotic, inflammatory, and cardiovascular risk markers. In this study, we examined the effects of hydrophilic rosuvastatin (RSV) and lipophilic pitavastatin (PTV) on these markers in patients with hypercholesterolemia. Methods The present study was a sub-analysis of our previous STAT-LVDF study. The subjects were treated with RSV or PTV for 24weeks. Changes in glucose-lipid metabolism, serum levels of SAA-LDL and AT-LDL, and C-reactive protein (CRP) level were assessed. Results In total, 53 patients were analyzed in the present study. RSV and PTV significantly decreased SAA-LDL (RSV: p =0.003, PTV: p =0.012) and AT-LDL levels (RSV: p =0.013, PTV: p =0.037). Changes in SAA-LDL level were significantly and positively correlated with those in CRP in both the RSV ( r =0.549, p =0.003) and PTV ( r =0.576, p =0.004) groups. Moreover, a positive correlation between changes of SAA-LDL levels and those of HbA1c levels was observed in the PTV group ( r =0.442, p =0.030) but not in the RSV group ( r =−0.100, p =0.611). Conclusions Both hydrophilic rosuvastatin and lipophilic pitavastatin reduce serum levels of atherosclerotic and inflammatory markers. These findings also indicate differential effects of RSV and PTV on glucose tolerance.
Databáze: OpenAIRE
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