Effect of prednisolone on human bone marrow cultures
| Autor: | P. Farnes, B.E. Barker |
|---|---|
| Rok vydání: | 1965 |
| Předmět: |
medicine.medical_specialty
Cell division Nucleolus Prednisolone Endocrinology Diabetes and Metabolism Bone Marrow Cells Biology Tissue Culture Techniques Tissue culture Endocrinology Bone Marrow Internal medicine medicine Pharmacology Hyperplasia Macrophages Research Fibroblasts medicine.disease In vitro Basophilia medicine.anatomical_structure Bone marrow Cell Division medicine.drug |
| Zdroj: | Metabolism. 14:75-77 |
| ISSN: | 0026-0495 |
| DOI: | 10.1016/0026-0495(65)90083-1 |
| Popis: | Human bone marrow cultured in NCTC 109 and pooled human serum develops fibroblast-like cells, “macrophages” and limited proliferation of hemic cells. The addition of prednisolone 0.5 μg. to 50 μg./ml. results in increased proliferation of fibroblast-like cells in primary cultures. Morphologically, the steroid-treated cells are flat and squat, with large nucleoli, and frequently show in-creased cytoplasmic basophilia. The in-crease in cell growth observed in these cultures is in contrast to much of the experimental data regarding effects of glucocorticoids on other tissues in vitro. The mechanism(s) of action which result in this phenomenon are not known. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|