Facilitated physiological adaptation to prolonged circadian disruption through dietary supplementation with essence of chicken
| Autor: | Wanjing Zhang, Youxiang Mao, Zhengwei Fu, Jianguo Jiang, Yujian Shao, Paramjeet Singh, Fai Tsang, Tao Wu, Boda Kong, Liangfeng Huang, Cencen Yao |
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| Rok vydání: | 2015 |
| Předmět: |
Male
medicine.medical_specialty endocrine system Physiology Circadian clock Endogeny Biology Energy homeostasis Physiology (medical) Internal medicine Circadian Clocks medicine Animals Circadian rhythm Homeodomain Proteins Behavior Animal Period Circadian Proteins Adaptation Physiological Circadian Rhythm PER2 CLOCK Mice Inbred C57BL Endocrinology Liver Chickens PER1 |
| Zdroj: | Chronobiology international. 32(10) |
| ISSN: | 1525-6073 |
| Popis: | Synchrony between circadian and metabolic processes is critical to the maintenance of energy homeostasis. Studies on essence of chicken (EC), a chicken meat extract rich in proteins, amino acids and peptides, showed its effectiveness in alleviating fatigue and promoting metabolism. A recent study revealed that it facilitated the re-entrainment of clock genes (Bmal1, Cry1, Dec1, Per1 and Per2) in the pineal gland and liver in a rat model of circadian disruption. Here, we investigated the role of EC-facilitated circadian synchrony in the maintenance of the energy homeostasis using a mouse model of prolonged circadian disruption. Prolonged circadian disruption (12 weeks) resulted in hepatic maladaptation, manifested by a mild but significant (p |
| Databáze: | OpenAIRE |
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