Pre-clinical interaction of ayahuasca, a brew used in spiritual movements, with morphine and propofol
| Autor: | Ana Paula Salum Pires, Fúlvio Rieli Mendes, José Luiz Gomes do Amaral, Mauricio Yonamine, Júlia Movilla Pires, Elisaldo Araujo Carlini |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
lcsh:RS1-441
Dimethyltryptamine Pharmacology Serotonergic lcsh:Pharmacy and materia medica Pharmacological interactions β-Carbolines 03 medical and health sciences 0302 clinical medicine Pharmacokinetics Medicine 030212 general & internal medicine Hot plate test Propofol Analgesic effect ALUCINOGÊNICOS Morphine business.industry Ayahuasca Nociception business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Brazilian Journal of Pharmaceutical Sciences; Vol. 54 No. 1 (2018); e17174 Brazilian Journal of Pharmaceutical Sciences; Vol. 54 Núm. 1 (2018); e17174 Brazilian Journal of Pharmaceutical Sciences; v. 54 n. 1 (2018); e17174 Brazilian Journal of Pharmaceutical Sciences Universidade de São Paulo (USP) instacron:USP Brazilian Journal of Pharmaceutical Sciences, Volume: 54, Issue: 1, Article number: e17174, Published: 07 JUN 2018 Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Brazilian Journal of Pharmaceutical Sciences, Vol 54, Iss 1 (2018) |
| ISSN: | 2175-9790 1984-8250 |
| Popis: | Ayahuasca is a beverage with psychoactive properties used in religious and ceremonial rituals by some religious groups. The main active components of ayahuasca are dimethyltryptamine and the harmala alkaloids with β-carboline structure acting as monoamine oxidase A inhibitors. This combination produces a pronounced activation of serotonergic pathways and presents potential interaction with other psychotropics. The objective of this study was to investigate the possible interactions between ayahuasca and agents employed in general anesthesia. The pharmacological interactions between ayahuasca and morphine or propofol were evaluated in mice using doses of 12, 120 and 1200 mg/kg (0.1 to 10 times the average dose consumed by humans in religious rituals). Ayahuasca alone showed an antinociceptive effect in the writhing and formalin tests, and intensified the analgesic effect of morphine in the hot plate test. Concerning the pharmacological interactions between ayahuasca and propofol, the results were opposite; ayahuasca intensified the depressant effect of propofol in the rotarod test, but decreased the sleeping time induced by propofol. These set of results showed the occurrence of some interactions between ayahuasca and the drugs morphine and propofol, possibly by both pharmacokinetics and pharmacodynamics mechanisms. |
| Databáze: | OpenAIRE |
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