Aspirin, but not propranolol, attenuates the acute stress-induced increase in circulating levels of interleukin-6: A randomized, double-blind, placebo-controlled study
| Autor: | Joachim E. Fischer, Roland von Känel, Monika Stutz, Daniel Preckel, Brigitte M. Kudielka, Petra Metzenthin, Susanne Helfricht, André Haeberli |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Hydrocortisone Neuroimmunomodulation Rest Adrenergic beta-Antagonists Immunology Placebo-controlled study Blood Pressure Propranolol Placebo Placebos Behavioral Neuroscience Double-Blind Method Trier social stress test Humans Medicine Interleukin 6 Aspirin biology Interleukin-6 Endocrine and Autonomic Systems business.industry Anti-Inflammatory Agents Non-Steroidal Interleukin Middle Aged Blood pressure Cardiovascular Diseases Anesthesia Acute Disease biology.protein Female business Stress Psychological medicine.drug |
| Zdroj: | Brain, Behavior, and Immunity. 22:150-157 |
| ISSN: | 0889-1591 |
| Popis: | Psychosocial stress might increase the risk of atherothrombotic events by setting off an elevation in circulating levels of the proinflammatory cytokine interleukin (IL)-6. We investigated the effect of aspirin and propranolol on the responsiveness of plasma IL-6 levels to acute psychosocial stress. For 5 days, 64 healthy subjects were randomized, double-blind, to daily oral aspirin 100mg plus long-acting propranolol 80 mg, aspirin 100mg plus placebo, long-acting propranolol 80 mg plus placebo, or placebo plus placebo. Thereafter, all subjects underwent the 13-min Trier Social Stress Test, which combines a preparation phase, a job interview, and a mental arithmetic task. Plasma IL-6 levels were measured in blood samples collected immediately pre- and post-stress, and 45 min and 105 min thereafter. The change in IL-6 from pre-stress to 105 min post-stress differed between subjects with aspirin medication and those without (p =0.033; eta p2=0.059). IL-6 levels increased less from pre-stress to 105 min post-stress (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect