Growth-differentiation factor-15, endoglin and N-terminal pro-brain natriuretic peptide induction in athletes participating in an ultramarathon foot race

Autor:	Maria Tsironi, Ioannis Papassotiriou, Photis Beris, Katerina Skenderi, Isabelle Tchou, Christina Kanaka-Gantenbein, Alexandra Margeli, Marc Barnet
Rok vydání:	2009
Předmět:	Adult Male medicine.medical_specialty Growth Differentiation Factor 15 Endothelium medicine.drug_class Health Toxicology and Mutagenesis Clinical Biochemistry Receptors Cell Surface Physical exercise Biochemistry Antigens CD Internal medicine Natriuretic Peptide Brain Natriuretic peptide Humans Medicine Exercise business.industry Endoglin Endothelial Cells Plasma levels Middle Aged Brain natriuretic peptide Peptide Fragments medicine.anatomical_structure Endocrinology Athletes Endothelium Vascular GDF15 business N-terminal pro-Brain Natriuretic Peptide
Zdroj:	Biomarkers. 14:418-422
ISSN:	1366-5804 1354-750X
DOI:	10.1080/13547500903062976
Popis:	We investigated the actions of growth-differentiation factor (GDF)-15, endoglin and N-terminal pro-brain natriuretic peptide (NT-pro-BNP) in 15 male athletes who participated in the ultradistance foot race of the 246 km 'Sparthathlon'. Measurements were performed before (phase I), at the end of the race (phase II) and 48 h post-race (phase III). GDF-15 and endoglin serum concentrations were determined with enzyme-linked immunosorbent assay and NT-pro-BNP plasma levels by electrochemiluminescence. GDF-15 levels were increased from phase I (563.9 +/- 57.1 pg ml(-1)) to phase II (2311.1 +/- 462.3 pg ml(-1)) and decreased at phase III (862.0 +/- 158.0 pg ml(-1)) (p0.0002). NT-pro-BNP levels followed a similar pattern to that of GDF-15 from 38.1 +/- 4.8 pg ml(-1) at phase I to 1280.6 +/- 259.0 pg ml(-1) at phase II and 89.8 +/- 13.6 pg ml(-1) at phase III (p0.0001) and at the same time points, endoglin levels were 4.7 +/- 0.2 ng ml(-1) at phase I, 5.8 +/- 0.2 ng ml(-1) at phase II and 4.3 +/- 0.2 ng ml(-1) at phase III (p0.002). These findings indicate that circulating GDF-15, endoglin and NT-pro-BNP levels reflect a transient endothelial dysfunction in these athletes who participated in a foot race consisting of continuous, prolonged and brisk exercise.
Databáze:	OpenAIRE
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