Alpha-glucosidase inhibitory anthranols, kenganthranols A-C, from the stem bark of Harungana madagascariensis
| Autor: | M. Iqbal Choudhary, Bonaventure T. Ngadjui, Deccaux G. W. F. Kapche, Seema Zareem, Shamsun Nahar Khan, Karsten Krohn, and Amal M. Y. Moustafa, Diane Beatrice Yapna, Simeon F. Kouam |
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| Rok vydání: | 2006 |
| Předmět: |
Stereochemistry
Pharmaceutical Science Anthraquinones Saccharomyces cerevisiae Pharmacognosy Analytical Chemistry chemistry.chemical_compound Clusiaceae Drug Discovery Harungana Phenols Cameroon Enzyme Inhibitors Pharmacology Plants Medicinal biology Organic Chemistry Biological activity alpha-Glucosidases Anthralin biology.organism_classification Terpenoid Complementary and alternative medicine chemistry Alpha-glucosidase visual_art biology.protein visual_art.visual_art_medium Plant Bark Molecular Medicine Bark |
| Zdroj: | Journal of natural products. 69(2) |
| ISSN: | 0163-3864 |
| Popis: | One new prenylated 1,4-anthraquinone and three new prenylated anthranols, named kengaquinone (1) and kenganthranols A (2), B (3), and C (4), were isolated from a hexane extract of the stem bark of Harungana madagascariensis. Six known compounds including anthraquinones, anthrones, and xanthones were also isolated and identified. The structures of the new compounds were determined by analysis of spectroscopic data and comparison with data of previously known analogues. Some isolated compounds (3-5, 7-11) were evaluated for their alpha-glucosidase inhibition activity. Compounds 3, 4, 8, and 11 showed significant activity, whereas compounds 7, 9, and 10 were inactive in this test. |
| Databáze: | OpenAIRE |
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