Trends and Factors Associated With Receipt of Upfront Surgery for Stage II to III Rectal Adenocarcinoma in the United States, 2006 to 2016
| Autor: | Michael R. Folkert, Nina N. Sanford, Todd A. Aguilera, Chul Ahn, David M. Hein |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Colorectal cancer Adenocarcinoma Logistic regression Time-to-Treatment Cohort Studies 03 medical and health sciences 0302 clinical medicine Biopsy Rectal Adenocarcinoma Adjuvant therapy Humans Medicine 030212 general & internal medicine Digestive System Surgical Procedures Aged Neoplasm Staging Aged 80 and over medicine.diagnostic_test Rectal Neoplasms business.industry Cancer Odds ratio Middle Aged medicine.disease Confidence interval Surgery Survival Rate Oncology 030220 oncology & carcinogenesis Female business Follow-Up Studies |
| Zdroj: | American Journal of Clinical Oncology. 44:187-194 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/coc.0000000000000808 |
| Popis: | INTRODUCTION The German rectal study published in 2004 established neoadjuvant chemoradiation as a standard of care for locally advanced rectal cancer and current National Comprehensive Cancer Network guidelines endorse several preoperative regimens. Upfront surgery, however, is considered substandard care. In the era of evolving treatment paradigms for locally advanced rectal cancer, we sought to assess trends and predictors of receipt of upfront surgery for stage II to III rectal cancer. METHODS The National Cancer Database was used to identify patients diagnosed with clinical stage II to III rectal adenocarcinoma between 2006 and 2016. Multivariable logistic regression defined adjusted odds ratios and associated 95% confidence intervals of receipt of upfront definitive surgery. The timing of upfront surgery relative to day of diagnosis and rate of receipt of adjuvant therapy were also estimated. RESULTS Among 51,562 patients, 6411 (12.4%) were treated with upfront surgery, which decreased from 16.7% in 2006 to 7.1% in 2016 (P |
| Databáze: | OpenAIRE |
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