Calpains and Delayed Calcium Deregulation in Excitotoxicity
| Autor: | Inês M. Araújo, Bruno P. Carreira, Caetana M. Carvalho, Arsélio P. Carvalho |
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| Rok vydání: | 2010 |
| Předmět: |
Proteases
Programmed cell death biology Calpain Traumatic brain injury Neurodegeneration Glutamate receptor Excitotoxicity General Medicine medicine.disease medicine.disease_cause Biochemistry Neuroprotection Enzyme Activation Cellular and Molecular Neuroscience Receptors Glutamate medicine biology.protein Animals Homeostasis Humans Calcium Neuroscience |
| Zdroj: | Neurochemical Research. 35:1966-1969 |
| ISSN: | 1573-6903 0364-3190 |
| Popis: | Overactivation of glutamate receptors results in neurodegeneration in a variety of brain pathologies, including ischemia, epilepsy, traumatic brain injury and slow-progressing neurodegenerative disorders. In all these pathologies, it is well accepted that the calcium-dependent cysteine proteases calpains are key players in the mechanisms of neuronal cell death. Many research groups have been actively pursuing to establish a link between the deregulation of intracellular Ca(2+) homeostasis associated with excitotoxicity and calpain activity. It is well established that these two events are connected and interact synergistically to promote neurodegeneration, but whether calpain activity depends on or contributes to Ca(2+) deregulation is still under debate. |
| Databáze: | OpenAIRE |
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