Renal Resistive Index Is Associated With Inactive Matrix Gla (γ-Carboxyglutamate) Protein in an Adult Population-Based Study
| Autor: | David A, Jaques, Edward, Pivin, Menno, Pruijm, Daniel, Ackermann, Idris, Guessous, Georg, Ehret, Fang-Fei, Wei, Jan A, Staessen, Antoinette, Pechère-Bertschi, Cees, Vermeer, Bruno, Vogt, Michel, Burnier, Pierre-Yves, Martin, Murielle, Bochud, Belen, Ponte |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Nephrology and Kidney pulse wave velocity 610 Medicine & health Pulse Wave Analysis renal physiology Vascular stiffness Renal Artery Sex Factors Vascular Stiffness Cardiovascular Disease Ultrasound Diabetes Mellitus Humans Aged Original Research ddc:613 ddc:616 Extracellular Matrix Proteins Kidney in Cardiovascular Disease renal resistive index Calcium-Binding Proteins Matrix Gla (γ‐carboxyglutamate) protein matrix Gla (γ‐carboxyglutamate) protein Renal resistive index Ultrasonography Doppler pulse pressure Middle Aged Atherosclerosis Renal physiology Pulse wave velocity Pulse pressure Hypertension Female Vascular Resistance atherosclerosis human activities Blood Flow Velocity Switzerland Biomarkers |
| Zdroj: | Journal of the American Heart Association, Vol. 8, No 18 (2019) P. e013558 Jaques, David A.; Pivin, Edward; Pruijm, Menno; Ackermann, Daniel; Guessous, Idris; Ehret, Georg; Wei, Fang-Fei; Staessen, Jan A.; Pechère-Bertschi, Antoinette; Vermeer, Cees; Vogt, Bruno; Burnier, Michel; Martin, Pierre-Yves; Bochud, Murielle; Ponte, Belen (2019). Renal Resistive Index Is Associated With Inactive Matrix Gla (γ-Carboxyglutamate) Protein in an Adult Population-Based Study. Journal of the American Heart Association, 8(18), pp. 1-15. American Heart Association 10.1161/JAHA.119.013558 Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| ISSN: | 2047-9980 |
| DOI: | 10.7892/boris.137899 |
| Popis: | Background Increased renal resistive index (RRI) has been associated with target organ damage as well as renal and cardiovascular outcomes. Matrix Gla (γ-carboxyglutamate) protein (MGP) is a strong inhibitor of soft tissue calcification. Its inactive form (dephospho-uncarboxylated MGP [dp-ucMGP]) has been associated with vascular stiffness, cardiovascular outcomes, and mortality. In this study, we hypothesized that high levels of dp-ucMGP were associated with increased RRI. Methods and Results We recruited participants via a multicenter family-based cross-sectional study in Switzerland. Levels of dp-ucMGP were measured in plasma by sandwich ELISA. RRI was measured by Doppler ultrasound in 3 segmental arteries in both kidneys. We used mixed regression models to assess the relationship between dp-ucMGP and RRI. We adjusted for common determinants of RRI as well as renal function and cardiovascular risk factors. We included 1006 participants in our analyses: 526 women and 480 men. Mean values were 0.44±0.20 nmol/L for dp-ucMGP and 64±5% for RRI. After multivariable adjustment, dp-ucMGP was positively associated with RRI (P=0.001). In subgroup analysis by age tertiles, this association was not significant in the youngest age group (55 years; P=0.016 and P |
| Databáze: | OpenAIRE |
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