ABO blood types and sepsis mortality
| Autor: | Sofie Louise Rygård, Thomas Mohr, Daniel I. Sessler, Jens-Ulrik Stæhr Jensen, Jens D Lundgren, Hami Tousi, Pär I. Johansson, Lars Broksø Holst, Ashish Khanna, Lars Hein, Theis Skovsgaard Itenov, Anne Lindhardt, Mads H. Andersen, Morten H. Bestle, Sisse R. Ostrowski, Ole Birger Pedersen, Christian Erikstrup |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine Lower risk Gastroenterology Sepsis Anaesthesia 03 medical and health sciences 0302 clinical medicine Blood type Intensive care Internal medicine ABO blood group system Septic shock medicine 030212 general & internal medicine Mortality business.industry RC86-88.9 Research Acute kidney injury Retrospective cohort study Medical emergencies. Critical care. Intensive care. First aid medicine.disease business |
| Zdroj: | Itenov, T S, Sessler, D I, Khanna, A K, Ostrowski, S R, Johansson, P I, Erikstrup, C, Pedersen, O B, Rygård, S L, Holst, L B, Bestle, M H, Hein, L, Lindhardt, A, Tousi, H, Andersen, M H, Mohr, T, Lundgren, J D & Jensen, J U 2021, ' ABO blood types and sepsis mortality ', Annals of Intensive Care, vol. 11, no. 1, 61 . https://doi.org/10.1186/s13613-021-00844-2 Annals of Intensive Care, Vol 11, Iss 1, Pp 1-9 (2021) Itenov, T S, Sessler, D I, Khanna, A K, Ostrowski, S R, Johansson, P I, Erikstrup, C, Pedersen, O B, Rygård, S L, Holst, L B, Bestle, M H, Hein, L, Lindhardt, A, Tousi, H, Andersen, M H, Mohr, T, Lundgren, J D & Jensen, J-U 2021, ' ABO blood types and sepsis mortality ', Annals of Intensive Care, vol. 11, no. 1, 61 . https://doi.org/10.1186/s13613-021-00844-2 Annals of Intensive Care |
| Popis: | Background We aimed to determine if the ABO blood types carry different risks of 30-day mortality, acute kidney injury (AKI), and endothelial damage in critically ill patients with sepsis. This was a retrospective cohort study of three independent cohorts of critically ill patients from the United States and Scandinavia consisting of adults with septic shock. We compared the 30-day mortality across the blood types within each cohort and pooled the results in a meta-analysis. We also estimated the incidence of AKI and degree of endothelial damage, as measured by blood concentrations of soluble thrombomodulin and syndecan-1. Results We included 12,342 patients with severe sepsis. In a pooled analysis blood type B carried a slightly lower risk of 30-day all-cause mortality compared to non-blood type B (adjusted HR 0.88; 95%-CI 0.79–0.98; p = 0.02). There was no difference in the risk of AKI. Soluble thrombomodulin and syndecan-1 concentrations were lower in patients with blood type B and O compared to blood type A, suggesting less endothelial damage. Conclusion Septic patients with blood type B had less endothelial damage, and a small reduction in mortality. The exposure is, however, unmodifiable. |
| Databáze: | OpenAIRE |
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