Resistance toLeishmania major infection correlates with the induction of nitric oxide synthase in murine macrophages
| Autor: | Clive Parkinson, Mark V. Rogers, Foo Y. Liew, David W. Moss, Salvador Moncada, Yun Li |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Leishmania tropica
medicine.medical_treatment Immunology Leishmaniasis Cutaneous Mice Inbred Strains Nitric Oxide Nitric oxide Microbiology Interferon-gamma Mice chemistry.chemical_compound Cutaneous leishmaniasis medicine Animals Immunology and Allergy Macrophage Leishmania major Immunity Cellular biology Tumor Necrosis Factor-alpha Macrophages Hydrogen Peroxide Macrophage Activation biology.organism_classification medicine.disease Recombinant Proteins Nitric oxide synthase Cytokine chemistry Enzyme Induction biology.protein Tumor necrosis factor alpha Amino Acid Oxidoreductases Nitric Oxide Synthase |
| Zdroj: | European Journal of Immunology. 21:3009-3014 |
| ISSN: | 1521-4141 0014-2980 |
| DOI: | 10.1002/eji.1830211216 |
| Popis: | Inbred strains of mice differ considerably in their innate resistance to leishmanial infection. BALB/c mice are highly susceptible to cutaneous leishmaniasis caused by Leishmania major, whereas CBA mice are resistant. We now show that this resistance correlates with the ability of macrophages to synthesize nitric oxide (NO) following activation with interferon-gamma or tumor necrosis factor alpha. Furthermore, the larger amounts of NO generated by resistant macrophages are related to higher levels of NO synthase activity, a difference which is not attributable to the number or the affinity of the receptors for interferon-gamma on these cells. The level of NO synthesis by activated macrophages was also correlated to the resistance in a number of other inbred mouse strains tested; macrophages from the resistant B10.S, C57BL and C3H mice produced significantly higher levels of NO than the macrophages from the susceptible BALB.b and DBA/2 mice. |
| Databáze: | OpenAIRE |
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