Reversal of corticosteroid-induced diabetes mellitis with supplemental chromium
| Autor: | N. A. Bryden, Nitsa Mirsky, L. Slezak, R. A. Anderson, A. Ravina |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Adult
Chromium Male inorganic chemicals medicine.medical_specialty medicine.drug_class Endocrinology Diabetes and Metabolism medicine.medical_treatment Urinary system Dietary Chromium chemistry.chemical_element Pilot Projects Chromium deficiency Endocrinology Adrenal Cortex Hormones Diabetes mellitus Internal medicine Diabetes Mellitus otorhinolaryngologic diseases Internal Medicine medicine Humans business.industry Insulin technology industry and agriculture Middle Aged medicine.disease chemistry Dietary Supplements Corticosteroid Female business Steroid diabetes |
| Zdroj: | Diabetic Medicine. 16:164-167 |
| ISSN: | 1464-5491 0742-3071 |
| DOI: | 10.1046/j.1464-5491.1999.00004.x |
| Popis: | Summary Aims To determine if the stress of corticosteroid treatment increases chromium (Cr) losses and if corticosteroid-induced diabetes (steroid diabetes) can be reversed by supplemental chromium. Methods The effects of corticosteroid treatment on chromium losses of 13 patients 2 days prior to steroid administration and the first 3 days following treatment were determined. Since steroid-induced diabetes was associated with increased chromium losses and insufficient dietary chromium is associated with glucose intolerance and diabetes, we treated three patients with steroid-induced diabetes with 600 μg per day of chromium as chromium picolinate. Results Urinary chromium losses following corticosteroid treatment increased from 155 ± 28 ng/d before corticosteroid treatment to 244 ± 33 ng/d in the first 3 days following treatment. Chromium supplementation of patients with steroid-induced diabetes resulted in decreases in fasting blood glucose values from greater than 13.9 mmol/l (250 mg/dl) to less than 8.3 mmol/l (150 mg/dl). Hypoglycaemic drugs were also reduced 50% in all patients when given supplemental chromium. Conclusions These data demonstrate that corticosteroid treatment increases chromium losses and that steroid-induced diabetes can be reversed by chromium supplementation. Follow-up, double-blind studies are needed to confirm these observations. Diabet. Med. 16, 164–167 (1999) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text