How Octogenarians with Bladder Cancer Are Treated in a Maximum-Care Hospital: The Real-Life Experience
| Autor: | Ricarda Merten, F. Steffen Krause, Verena Lieb, Oliver J. Ott, Bernd Wullich, Frank Kunath, Sven Wach, Helge Taubert, Bastian Keck, Danijel Sikic, Mario Richterstetter, Rainer Fietkau |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Risk
medicine.medical_specialty Urology medicine.medical_treatment 030232 urology & nephrology Kaplan-Meier Estimate Cystectomy 03 medical and health sciences Life Expectancy fluids and secretions 0302 clinical medicine Surgical oncology Medizinische Fakultät medicine Carcinoma Humans Neoplasm Invasiveness Neoplasm Staging Retrospective Studies Aged 80 and over Geriatrics ddc:616 Bladder cancer business.industry Muscles General surgery Retrospective cohort study medicine.disease Hospitals Radiation therapy Surgical Oncology Treatment Outcome Urinary Bladder Neoplasms 030220 oncology & carcinogenesis embryonic structures Life expectancy Urothelium business Follow-Up Studies |
| Popis: | Introduction: With increasing life expectancy, curative treatment of octogenarians with urothelial carcinoma of the bladder (UCB) becomes more important. Materials and Methods: The treatment modalities of 276 octogenarians with UCB who were treated at the University Hospital of Erlangen between 1982 and 2011 were assessed retrospectively. Results: One hundred forty-six patients had non-muscle invasive bladder cancer (NMIBC) while 71 had muscle invasive bladder cancer (MIBC). No data was available for 59 patients. Eighty-five (58.2%) of the 146 patients with NMIBC received transurethral resection of the bladder tumor (TURBT) only, another 38 patients (26%) underwent additional intravesical therapy; and 8.9% were treated with radiochemotherapy (RCT), 4.1% with radiotherapy (RT), 1.4% with systemic chemotherapy and 1.4% with radical cystectomy (RC). Of the 71 patients suffering from MIBC, 39 (54.9%) received TURBT alone. A potentially curative therapy was performed on 31 of the 71 patients with MIBC (43.7%). Of these, 16 patients (51.6%) received RCT, 9 patients (29.0%) RT and 6 patients (19.4%) RC. In Kaplan-Meier analysis, patients with MIBC had better median overall survival with curative treatment compared to TURBT alone (28 vs. 9 months; p < 0.001, log-rank test). Conclusions: By offering a wide range of treatment options, over 43% of octogenarians with MIBC received a curative therapy at a maximum care hospital. |
| Databáze: | OpenAIRE |
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